Trial reportBMC complementary medicine and therapies2024
Effects of aromatherapy with Matricaria chamomile essential oil on anxiety and hemodynamic indices in patients with acute coronary syndrome, 2021: a randomized controlled trial.
Trial report in BMC complementary medicine and therapies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Effects of aromatherapy on objective physiological outcomes in adult ICU patients: a systematic review.Frontiers in medicine · 2026Pooled it
- Attitudes of Surgical Nurses Toward Non-Pharmacological Postoperative Pain Management: A Descriptive Cross-Sectional Study.Nursing reports (Pavia, Italy) · 2026Article
- Effect of aromatherapy with Matricaria chamomilla in pain and anxiety management in hospital settings: A scoping review protocol.PloS one · 2026Article
- The Efficacy of Aromatherapy in Alleviating Anxiety among Acute Myocardial Infarction Patients: A Systematic Review and Meta-Analysis.Acta Cardiologica Sinica · 2025Review
- Effects of inhalingFrontiers in psychology · 2025Article
- Review
- The Effect of Oral Chamomile on Anxiety: A Systematic Review of Clinical Trials.Clinical nutrition research · 2024Review
- Examining the Effect of an Orientation Tour and Aromatherapy on Stress and Depressed Mood in Birthing Parents with Preterm Infants: A Quasi-Experimental Study.Iranian journal of nursing and midwifery researchArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with Acute Coronary Syndrome (ACS) experience high levels of anxiety that may cause instability of hemodynamic indices, increased risk of ischemia, myocardial infarction and poor quality of life. Aromatherapy can affect patients' anxiety levels and improve hemodynamic indices. This study aimed to evaluate the efficacy of aromatherapy on anxiety and hemodynamic indices in ACS patients.
methodsThis study was a double-blind, randomized clinical trial conducted on 154 ACS patients. The participants were classified into two equal groups of intervention and placebo through the block randomization method. The data collection tools consisted of demographic information, a shortened 6-item version of the Spielberger questionnaire and a form of hemodynamic indices. For two consecutive nights, the intervention group inhaled 7 drops of the chamomile essential oil (%10) and the placebo group inhaled 7 drops of the sesame oil poured on a sterile cotton ball. The hemodynamic indices were collected half an hour before, one and four hours after the intervention until the next morning. The Spielberger questionnaire was completed once before the intervention and once after the end of the intervention, by the researcher through an interview. The number of heart rate (HR) was counted for a full minute. Also, the blood pressure (BP) of all the samples was measured by the researcher. Data analysis was done using Chi-square, paired t-test, and analysis of variance (ANOVA) in SPSS
resultsThe mean and standard deviation of the age of patients were 58/2 ± 11.6 and 59.7% of them were female. The results of ANOVA showed a significantly lower anxiety score as well as systolic blood pressure (SBP), diastolic blood pressure (DBP) and HR in the intervention group compared to those of the placebo group (P < 0.001). The decrease in anxiety score after the intervention, in the intervention and placebo groups was (5.2 ± 1.9) and (1 ± 1. 18) respectively. In the intervention group, the SBP and DBP after the intervention, was significant (P < 0.05). Also, the HR was significant (P < 0.001) after the intervention.
conclusionsAromatherapy could reduce anxiety and improve hemodynamic indices in ACS patients.
trial registrationIRCT20080825001083N11.
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