Evidence map›Paper›PMID 38172782›Full record

ArticleBMC veterinary research2024

Analysis of fecal microbiome and metabolome changes in goats with pregnant toxemia.

Bingyan Jin, Ruoqian Wang, Jiada Hu, Yan Wang, Panpan Cheng, Jiancong Zhang, Jiahui Zhang, Gang Xue, Yan Zhu, Yunhai Zhang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Bingyan JinAnhui Provincial Key Laboratory of Local Livestock Poultry, Genetical Resource Conservation and Breeding, College of Animal Science and Technology, Anhui Agriculture University, 130 Changjiang West Road, 230036, Hefei, Anhui, China.
Ruoqian WangAnhui Provincial Key Laboratory of Local Livestock Poultry, Genetical Resource Conservation and Breeding, College of Animal Science and Technology, Anhui Agriculture University, 130 Changjiang West Road, 230036, Hefei, Anhui, China.
Jiada HuAnhui Provincial Key Laboratory of Local Livestock Poultry, Genetical Resource Conservation and Breeding, College of Animal Science and Technology, Anhui Agriculture University, 130 Changjiang West Road, 230036, Hefei, Anhui, China.
Yan WangAnhui Provincial Key Laboratory of Local Livestock Poultry, Genetical Resource Conservation and Breeding, College of Animal Science and Technology, Anhui Agriculture University, 130 Changjiang West Road, 230036, Hefei, Anhui, China.
Panpan ChengAnhui Provincial Key Laboratory of Local Livestock Poultry, Genetical Resource Conservation and Breeding, College of Animal Science and Technology, Anhui Agriculture University, 130 Changjiang West Road, 230036, Hefei, Anhui, China.
Jiancong ZhangAnhui Provincial Key Laboratory of Local Livestock Poultry, Genetical Resource Conservation and Breeding, College of Animal Science and Technology, Anhui Agriculture University, 130 Changjiang West Road, 230036, Hefei, Anhui, China.
Jiahui ZhangAnhui Provincial Key Laboratory of Local Livestock Poultry, Genetical Resource Conservation and Breeding, College of Animal Science and Technology, Anhui Agriculture University, 130 Changjiang West Road, 230036, Hefei, Anhui, China.
Gang XueAnhui Provincial Key Laboratory of Local Livestock Poultry, Genetical Resource Conservation and Breeding, College of Animal Science and Technology, Anhui Agriculture University, 130 Changjiang West Road, 230036, Hefei, Anhui, China.
Yan ZhuAnhui Provincial Key Laboratory of Local Livestock Poultry, Genetical Resource Conservation and Breeding, College of Animal Science and Technology, Anhui Agriculture University, 130 Changjiang West Road, 230036, Hefei, Anhui, China.
Yunhai ZhangAnhui Provincial Key Laboratory of Local Livestock Poultry, Genetical Resource Conservation and Breeding, College of Animal Science and Technology, Anhui Agriculture University, 130 Changjiang West Road, 230036, Hefei, Anhui, China.
Fugui FangAnhui Provincial Key Laboratory of Local Livestock Poultry, Genetical Resource Conservation and Breeding, College of Animal Science and Technology, Anhui Agriculture University, 130 Changjiang West Road, 230036, Hefei, Anhui, China.
Ya LiuAnhui Provincial Key Laboratory of Local Livestock Poultry, Genetical Resource Conservation and Breeding, College of Animal Science and Technology, Anhui Agriculture University, 130 Changjiang West Road, 230036, Hefei, Anhui, China. liuya@ahau.edu.cn.
Yunsheng LiAnhui Provincial Key Laboratory of Local Livestock Poultry, Genetical Resource Conservation and Breeding, College of Animal Science and Technology, Anhui Agriculture University, 130 Changjiang West Road, 230036, Hefei, Anhui, China. lys@ahau.edu.cn.
Anhui Agricultural University · CN

Funding

Major Science and Technology Project of Bozhou City BZSKXJSJ2020-62Major Science and Technology Special Project of Anhui Province 202103B06020023National Natural Science Foundation of China 31972629National Natural Science Foundation of China 32272881Tejinke project in Linquan LQRJK2021-02
6 · The paper itself

Abstract

backgroundPregnancy toxemia is a common disease, which occurs in older does that are pregnant with multiple lambs in the third trimester. Most of the sick goats die within a few days, which can seriously impact the economic benefits of goat breeding enterprises. The disease is believed to be caused by malnutrition, stress, and other factors, that lead to the disorder of lipid metabolism, resulting in increased ketone content, ketosis, ketonuria, and neurological symptoms. However, the changes in gut microbes and their metabolism in this disease are still unclear. The objective of this experiment was to evaluate the effect of toxemia of pregnancy on the fecal microbiome and metabolomics of does.

resultsEight pregnant does suspected of having toxemia of pregnancy (PT group) and eight healthy does during the same pregnancy (NC group) were selected. Clinical symptoms and pathological changes at necropsy were observed, and liver tissue samples were collected for pathological sections. Jugular venous blood was collected before morning feeding to detect biochemical indexes. Autopsy revealed that the liver of the pregnancy toxemia goat was enlarged and earthy yellow, and the biochemical results showed that the serum levels of aspartate aminotransferase (AST) and β-hydroxybutyric acid (B-HB) in the PT group were significantly increased, while calcium (Ca) levels were significantly reduced. Sections showed extensive vacuoles in liver tissue sections. The microbiome analysis found that the richness and diversity of the PT microbiota were significantly reduced. Metabolomic analysis showed that 125 differential metabolites were screened in positive ion mode and enriched in 12 metabolic pathways. In negative ion mode, 100 differential metabolites were screened and enriched in 7 metabolic pathways.

conclusionsEvidence has shown that the occurrence of pregnancy toxemia is related to gut microbiota, and further studies are needed to investigate its pathogenesis and provide research basis for future preventive measures of this disease.

Indexed as

Goat DiseasesMicrobiotaPre-EclampsiaSheep DiseasesToxemiaAnimalsFemaleGoatsMetabolomeMetabolomicsPregnancyRNA, Ribosomal, 16SSheepSheep, DomesticRNA, Ribosomal, 16S16S rRNAMetabolomicsMicrobiomePregnancy toxemia

Identifiers

PMID38172782
PMCPMC10763682
OpenAlexW4390542486

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.