ArticleBMC nephrology2024
Blood stream Infections in chronic hemodialysis patients - characteristics and outcomes.
Article in BMC nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 14 citations in OpenAlex.
- Bacterial metagenomic analysis of patients with chronic kidney disease undergoing hemodialysis based on 16S rDNA amplicon sequencing.Biomedical reports · 2026Article
- Changes in Antibiotic Resistance Patterns in Diabetic Foot Infections Requiring Toe Amputation: A Long-Term Single-Center Retrospective Study.Antibiotics (Basel, Switzerland) · 2026Article
- Epidemiology, antimicrobial resistance, and mortality of bloodstream infections in hemodialysis patients: an 11-year retrospective cohort study from southern Saudi Arabia.BMC nephrology · 2026Article
- Seroprevalence and Demographic Distribution of Blood-Borne Viral Infections among Hemodialysis Patients in Sudan: A Multicenter Study from Conflict-Affected Khartoum State.Virology journal · 2026Article
- Risk Factors and Pathogenic Bacteria Prevalence in Catheter-Associated Blood Stream Infection in Patients Undergoing Hemodialysis: A Cross-Sectional Study.Health science reports · 2026Article
- Clinical Characteristics and Microbiology of Bloodstream Infections in Hemodialysis-Dependent Patients: A Multicenter Retrospective Study from Five Hemodialysis Centers in Saudi Arabia.Avicenna journal of medicine · 2026Article
- Predicting dialyzer fiber blocking is hard due to high intrapatient variability and limited utility of thrombin generation markers.Scientific reports · 2026Article
- Associations of CALLY, CLR, and CHR with all-cause mortality in patients receiving maintenance hemodialysis: a two-center retrospective cohort study.Frontiers in endocrinology · 2026Article
- Prognostic Factors for Mortality in Catheter-Related Bloodstream Infections Among Hemodialysis Patients: A Prospective Single-Center Study.Medicina (Kaunas, Lithuania) · 2025Article
- Clinical Implementation of an Adapted Infection Risk Screening Tool Following Nurse-Led Haemodialysis Vascular Access Consultation.Healthcare (Basel, Switzerland) · 2025Article
- Secular trends of bloodstream infections in hemodialysis patients: insights from a longitudinal Swiss study.Antimicrobial resistance and infection control · 2025Article
- Bacterial etiology and antimicrobial resistance in bloodstream infections at the University of Gondar Comprehensive Specialized Hospital: a cross-sectional study.Frontiers in microbiology · 2025Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBloodstream Infections (BSI) are a major cause of death and hospitalization among hemodialysis (HD) patients. The rates of BSI among HD patients vary and are influenced by local patient and pathogen characteristics. Modifications in local infection prevention protocols in light of active surveillance of BSI has been shown to improve clinical outcomes. The aim of this study was to further explore factors associated with BSI in a contemporary cohort of HD patients at a public teaching hospital dialysis center in Israel.
methodsThis was a retrospective cohort study of HD patients with a BSI in the years 2014 to 2018. The primary outcome was the occurrence of BSI. Secondary outcomes were to describe the causative pathogens of BSI, and to assess for risk factors for BSI, and mortality.
resultsIncluded were 251 patients. The mean age was 68.5 ± 13.4 years, 66.9% were male. The mean time from initiation of dialysis was 34.76 ± 40.77 months, interquartile range (IQR) 1-47.5 months and the follow up period of the cohort was 25.17 ± 15.9 months. During the observation period, 44 patients (17.5%) developed 54 BSI events, while 10 of them (3.9% of the whole cohort) developed recurrent BSI events. Gram-negative microorganisms caused 46.3% of all BSI events. 31.4% of these BSI were caused by resistant bacteria. In a multivariate logistic regression analysis, patients receiving dialysis through a central line had a significantly increased risk for BSI adjusted Odds Ratio (aOR) 3.907, p = 0.005, whereas patients' weight was mildly protective (aOR 0.971, p = 0.024).
conclusionsWe noted an increased prevalence of gram-negative pathogens in the etiology of BSI in HD patients. Based on our findings, additional empirical antibiotics addressing gram negative bacteria have been added to our empirical treatment protocol. Our findings highlight the need to follow local epidemiology for implementing appropriate preventative measures and for tailoring appropriate empiric antibiotic therapy.
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