Evidence map›Paper›PMID 38172671›Full record

ArticleBMC cardiovascular disorders2024

Association between hemoglobin A1c and abdominal aortic calcification: results from the National Health and Nutrition Examination Survey 2013-2014.

Can Cai, Lingsong Wang, Quanyao Chen, Min Lin, Xiuming Pan, Weida Chen, Danni Shi, Yao Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Can CaiScientific Research and Innovation Center, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, 361003, China.
Lingsong WangScientific Research and Innovation Center, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, 361003, China.
Quanyao ChenScientific Research and Innovation Center, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, 361003, China.
Min LinScientific Research and Innovation Center, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, 361003, China.
Xiuming PanScientific Research and Innovation Center, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, 361003, China.
Weida ChenScientific Research and Innovation Center, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, 361003, China.
Danni ShiScientific Research and Innovation Center, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, 361003, China.
Yao ChenScientific Research and Innovation Center, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, 361003, China. chenyaoxm@126.com.
Xiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHemoglobin A1c (HbA1c), a "gold standard" for the assessment of glycemic control, was associated with an increased risk of cardiovascular disease and coronary artery calcification. However, its effects on abdominal aortic calcification (AAC) are uncertain. The present study comprehensively investigated the association between HbA1c and AAC in the 2013-2014 National Health and Nutrition Examinations Surveys.

methodsAmong 1,799 participants ≥ 40 years, dual-energy X-ray absorptiometry-derived AAC was quantified using the Kauppila score (AAC-24). Severe AAC was defined as a total AAC-24 > 6. Weighted linear regression models and logistic regression models were used to determine the effects of HbA1c on AAC. The restricted cubic spline model was used for the dose-response analysis.

resultsThe mean AAC-24 of participants was 1.3, and 6.7% of them suffered from severe AAC. Both AAC-24 and the prevalence of severe AAC increased with the higher tertile of HbA1c (P < 0.001). Elevated HbA1c levels would increase the AAC-24 (β = 0.73, 95% CI: 0.30-1.16) and the risk of severe AAC (OR = 1.63, 95% CI: 1.29-2.06), resulting in nearly linear dose-response relationships in all participants. However, this positive correlation were not statistically significant when participants with diabetes were excluded. Furthermore, subgroup analysis showed significant interactions effect between HbA1c and hypertension on severe AAC with the OR (95% CI) of 2.35 (1.62-3.40) for normotensives and 1.39 (1.09-1.79) for hypertensives (P for interaction = 0.022).

conclusionControlling HbA1c could reduce AAC scores and the risk of severe AAC. Glycemic management might be a component of strategies for preventing AAC among all participants, especially normotensives.

Indexed as

Aortic DiseasesVascular CalcificationAorta, AbdominalGlycated HemoglobinHumansNutrition SurveysRisk FactorsGlycated HemoglobinAbdominal aortic calcificationCross-sectional studyHemoglobin A1cNHANES

Identifiers

PMID38172671
PMCPMC10765683
OpenAlexW4390532982

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.