SynthesisNature2024
Host genetic regulation of human gut microbial structural variation.
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed, 4 pooled it
33.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
120 citing papers in PubMed, 4 syntheses or guidelines pooled it, 144 citations in OpenAlex.
- Probiotic-Driven Competitive Exclusion in the Human Gut: A Meta-Analysis of Microbial Diversity and Pathogen Suppression.Nutrients · 2026Pooled it
- The impact of single nucleotide polymorphisms on the absorption, distribution, metabolism, and excretion of dietary (poly)phenols: a critical systematic review.Food & function · 2025Pooled it
- The Female Reproductive Tract Microbiota and Endometrial Cancer: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Meta-analysis of gut microbiome reveals patterns of dysbiosis in colorectal cancer patients.Journal of medical microbiology · 2025Pooled it
- Discovery of a secretedGut microbes · 2026Article
- Comparative insights into the gut-heart axis: cross-species and cross-population perspectives.Gut microbes · 2026Review
- Feasibility and pitfalls of combining small subpopulations for genome-wide association analysis of maize (Zea mays L.) kernel traits.The plant genome · 2026Article
- Drug-microbiome-host interactions: antimicrobial effects of non-antibiotic compounds.Nature reviews. Gastroenterology & hepatology · 2026Review
- Seasonal Variation of Gut Bacterial Community in WildEcology and evolution · 2026Article
- Bridging precision agriculture and human medicine through comparative genetics.Nature reviews. Genetics · 2026Review
- Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Emergent function, not microbial conformity: functional redundancy and the limits of taxonomic inference in microbiome genomics.Microbial genomics · 2026Review
- Microbiome features associated with persistent intestinal carriages of Escherichia coli ST131 in a Southeast Asian cohort study.Nature communications · 2026Article
- Host genetic architecture and gut microbiota cooperatively regulate early growth in goats.Animal microbiome · 2026Article
- Epigenetic phase variation in the gut microbiome enhances bacterial adaptation.Cell host & microbe · 2026Article
- Gut microbiome-blood cholesterol crosstalk: towards personalized strategies for dyslipidemia.Folia microbiologica · 2026Review
- Multi-omics analysis identifies key microbial taxa and host genes controlling abdominal fat deposition in chickens.Poultry science · 2026Article
- Molecular basis of precision nutrition: Food components, microbiome-derived metabolites, and multi-omics modeling.Food chemistry. Molecular sciences · 2026Review
- Review
- Microbiome biomarkers in autism spectrum disorder: Toward prediction, diagnosis, and prognosis.Cell reports. Medicine · 2026Review
60 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 5 institutions in 7 countries.
Daria V Zhernakova *University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.ORCID 0000-0001-6531-3890
Daoming Wang *University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.ORCID 0000-0003-4623-8527
Lei Liu *University of Groningen, University Medical Center Groningen, Department of Medical Microbiology and Infection Prevention, Groningen, The Netherlands.ORCID 0000-0002-8697-1128
Sergio Andreu-SánchezUniversity of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
Yue ZhangUniversity of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
Angel J Ruiz-MorenoUniversity of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.ORCID 0000-0002-2798-5386
Haoran PengUniversity of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.ORCID 0009-0002-7779-7073
Niels PlompUniversity of Groningen, University Medical Center Groningen, Department of Medical Microbiology and Infection Prevention, Groningen, The Netherlands.ORCID 0000-0003-1434-5010
Ángela Del Castillo-IzquierdoUniversity of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.ORCID 0000-0002-0140-1418
Ranko GacesaUniversity of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.ORCID 0000-0003-2119-0539
Esteban A Lopera-MayaUniversity of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
Godfrey S TembaDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Vesla I KullayaDepartment of Medical Biochemistry and Molecular Biology, Kilimanjaro Christian Medical University College, Moshi, Tanzania.
Sander S van LeeuwenUniversity of Groningen, University Medical Center Groningen, Department of Laboratory Medicine, Groningen, The Netherlands.
Lifelines Cohort Study
Ramnik J XavierBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-5630-5167
Quirijn de MastDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Leo A B JoostenDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0001-6166-9830
Niels P RiksenDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0001-9197-8124
Joost H W RuttenDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Mihai G NeteaDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0003-2421-6052
Serena SannaUniversity of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
Cisca WijmengaUniversity of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.ORCID 0000-0002-5635-1614
Rinse K WeersmaUniversity of Groningen, University Medical Center Groningen, Department of Gastroenterology and Hepatology, Groningen, The Netherlands.ORCID 0000-0001-7928-7371
Alexandra ZhernakovaUniversity of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
Hermie J M HarmsenUniversity of Groningen, University Medical Center Groningen, Department of Medical Microbiology and Infection Prevention, Groningen, The Netherlands. h.j.m.harmsen@umcg.nl.ORCID 0000-0003-2725-6148
Jingyuan FuUniversity of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands. j.fu@umcg.nl.ORCID 0000-0001-5578-1236
University Medical Center Groningen · NLRadboud University Nijmegen · NLBroad Institute · USKilimanjaro Christian Medical Centre · TZUniversity of Bonn · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the impact of host genetics on gut microbial diversity and the abundance of specific taxa is well established
Indexed as
BacteriaGastrointestinal MicrobiomeHost Microbial InteractionsMetagenomeABO Blood-Group SystemAcetylgalactosamineActinobacteriaCohort StudiesComputer SimulationFaecalibacterium prausnitziiGalactoside 2-alpha-L-fucosyltransferaseGalactosyltransferasesGenome, HumanGenotypeHumansIn Vitro TechniquesABO Blood-Group SystemABO protein, humanAcetylgalactosamineFUT2 protein, humanGalactoside 2-alpha-L-fucosyltransferaseGalactosyltransferases
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.