ArticleScientific reports2024
A transcriptomic analysis of skeletal muscle tissues reveals promising candidate genes and pathways accountable for different daily weight gain in Hanwoo cattle.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 20 citations in OpenAlex.
- Multi-Breed Genome-Wide Association Analysis Reveals Candidate Genes for Growth and Body Conformation Traits in Four Populations of Native and Crossbred Chinese Sheep.Animals : an open access journal from MDPI · 2026Article
- Genomic insights into the recent evolution and biodiversity of Italian sheep breeds.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- High-quality phased genome assemblies of line-bred Korean Hanwoo cattle.Scientific data · 2025Article
- Genomic insights on the history and selection trajectories of the Comune di Sicilia goat.BMC genomic data · 2025Article
- Genomic diversity and selection signatures in Asian Zebu Cattle: insights into adaptation and genetic erosion.Scientific reports · 2025Article
- Multi-Omics Analysis Revealed the Molecular Mechanisms Affecting Average Daily Gain in Cattle.International journal of molecular sciences · 2025Article
- Integration of Multiomics Data Reveals Selection Characteristics ofInternational journal of molecular sciences · 2025Article
- Integrated TWAS, GWAS, and RNAseq results identify candidate genes associated with reproductive traits in cows.Scientific reports · 2025Article
- Molecular signatures diversity unveiled through a comparative transcriptome analysis of longissimus dorsi and psoas major muscles in Hanwoo cattle.Animal biotechnology · 2024Article
- Estimation of Genetic Parameters of Early Growth Traits in Dumeng Sheep.Animals : an open access journal from MDPI · 2024Article
- Vitamin a potentiates sheep myoblasts myogenic differentiation through BHLHE40-modulated ID3 expression.BMC genomics · 2024Article
- Identification of Heilongjiang crossbred beef cattle pedigrees and reveals functional genes related to economic traits based on whole-genome SNP data.Frontiers in genetics · 2024Article
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5 authors at 2 institutions in 1 country.
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Abstract
Cattle traits like average daily weight gain (ADG) greatly impact profitability. Selecting based on ADG considering genetic variability can lead to economic and genetic advancements in cattle breeding. This study aimed to unravel genetic influences on ADG variation in Hanwoo cattle at the skeletal muscle transcriptomic level. RNA sequencing was conducted on longissimus dorsi (LD), semimembranosus (SB), and psoas major (PM) muscles of 14 steers assigned to same feed, grouped by low (≤ 0.71 kg) and high (≥ 0.77 kg) ADG. At P ≤ 0.05 and log2fold > 1.5, the distinct pattern of gene expression was identified with 184, 172, and 210 differentially expressed genes in LD, SB, and PM muscles, respectively. Tissue-specific responses to ADG variation were evident, with myogenesis and differentiation associated JAK-STAT signaling pathway and prolactin signaling pathways enriched in LD and SB muscles, while adipogenesis-related PPAR signaling pathways were enriched in PM muscle. Key hub genes (AXIN2, CDKN1A, MYC, PTGS2, FZD5, SPP1) were upregulated and functionally significant in muscle growth and differentiation. Notably, DPP6, CDKN1A, and FZD5 emerged as possible candidate genes linked to ADG variation. These findings enhance our understanding of genetic factors behind ADG variation in Hanwoo cattle, illuminating skeletal muscle mechanisms influencing ADG.
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