Evidence map›Paper›PMID 38172534›Full record

ArticleBritish journal of cancer2024

TSLP enhances progestin response in endometrial cancer via androgen receptor signal pathway.

Mu Lv, Yuan Xu, Peiqin Chen, Jingjie Li, Zuoshu Qin, Baozhu Huang, Yong Liu, Xiang Tao, Jun Xiang, Yanqiu Wang and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. TSLP: contrasting roles in cancer.Frontiers in immunology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Mu Lv *Reproductive Medicine Center, Department of Obstetrics and Gynecology, Tongji Hospital, School of Medicine, Tongji University, 200065, Shanghai, China.ORCID http://orcid.org/0000-0002-3215-3883
Yuan Xu *Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 200080, Shanghai, China.
Peiqin ChenDepartment of Obstetrics and Gynecology, The International Peace Maternity & Child Health Hospital of China Welfare Institute, Shanghai Jiao Tong University School of Medicine, 200030, Shanghai, China.
Jingjie LiDepartment of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 200080, Shanghai, China.
Zuoshu QinReproductive Medicine Center, Department of Obstetrics and Gynecology, Tongji Hospital, School of Medicine, Tongji University, 200065, Shanghai, China.
Baozhu HuangDepartment of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 200080, Shanghai, China.
Yong LiuDepartment of Radiation Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 200080, Shanghai, China.
Xiang TaoDepartment of Pathology, Obstetrics and Gynecology Hospital of Fudan University, 200090, Shanghai, China.
Jun XiangReproductive Medicine Center, Department of Obstetrics and Gynecology, Tongji Hospital, School of Medicine, Tongji University, 200065, Shanghai, China.
Yanqiu WangReproductive Medicine Center, Department of Obstetrics and Gynecology, Tongji Hospital, School of Medicine, Tongji University, 200065, Shanghai, China.
Youji FengDepartment of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 200080, Shanghai, China.
Wenxin ZhengDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Zhenbo ZhangReproductive Medicine Center, Department of Obstetrics and Gynecology, Tongji Hospital, School of Medicine, Tongji University, 200065, Shanghai, China. zhangzhenbozzb@aliyun.com.ORCID http://orcid.org/0000-0001-7245-3963
Linxia LiDepartment of Obstetrics and Gynecology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, 358 Datong Road, 200137, Shanghai, China. lilinxia@hosno7.com.
Hong LiaoDepartment of Clinical Laboratory Medicine, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, 200040, Shanghai, China. liaohonglp@aliyun.com.
Shanghai Jiao Tong University · CNTongji University · CNObstetrics and Gynecology Hospital of Fudan University · CNShanghai First Maternity and Infant Hospital · CNShanghai University of Traditional Chinese Medicine · CNThe University of Texas Southwestern Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe enriched proteins within in vitro fertilisation (IVF)-generated human embryonic microenvironment could reverse progestin resistance in endometrial cancer (EC).

methodsThe expression of thymic stromal lymphopoietin (TSLP) in EC was evaluated by immunoblot and IHC analysis. Transcriptome sequencing screened out the downstream pathway regulated by TSLP. The role of TSLP, androgen receptor (AR) and KANK1 in regulating the sensitivity of EC to progestin was verified through a series of in vitro and in vivo experiments.

resultsTSLP facilitates the formation of a BMP4/BMP7 heterodimer, resulting in activation of Smad5, augmenting AR signalling. AR in turn sensitises EC cells to progestin via KANK1. Downregulation of TSLP, loss of AR and KANK1 in EC patients are associated with tumour malignant progress. Moreover, exogenous TSLP could rescue the anti-tumour effect of progestin on mouse in vivo xenograft tumour.

conclusionsOur findings suggest that TSLP enhances the sensitivity of EC to progestin through the BMP4/Smad5/AR/KANK1 axis, and provide a link between embryo development and cancer progress, paving the way for the establishment of novel strategy overcoming progestin resistance using embryo original factors.

Indexed as

Endometrial NeoplasmsThymic Stromal LymphopoietinAdaptor Proteins, Signal TransducingAnimalsCytokinesCytoskeletal ProteinsFemaleHumansMiceProgestinsReceptors, AndrogenSignal TransductionTumor MicroenvironmentAdaptor Proteins, Signal TransducingCytokinesCytoskeletal ProteinsKANK1 protein, humanProgestinsReceptors, AndrogenThymic Stromal LymphopoietinTSLP protein, human

Identifiers

PMID38172534
PMCPMC10876595
OpenAlexW4390536559

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.