Evidence map›Paper›PMID 38172512›Full record

ArticleNature communications2024

Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques.

Rajeshwer S Sankhala, Kerri G Lal, Jaime L Jensen, Vincent Dussupt, Letzibeth Mendez-Rivera, Hongjun Bai, Lindsay Wieczorek, Sandra V Mayer, Michelle Zemil, Danielle A Wagner and 41 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

51 authors at 8 institutions in 1 country.

Rajeshwer S Sankhala *Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Kerri G Lal *Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Jaime L JensenEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.ORCID 0000-0002-8818-7513
Vincent DussuptEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Letzibeth Mendez-RiveraHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Hongjun BaiEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.ORCID 0000-0002-3501-3974
Lindsay WieczorekHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Sandra V MayerEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.ORCID 0000-0002-5767-8870
Michelle ZemilHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.ORCID 0000-0002-1700-6658
Danielle A WagnerVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-5819-1426
Samantha M TownsleyHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Agnes HajduczkiEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
William C ChangEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.ORCID 0000-0003-4967-6426
Wei-Hung ChenEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.ORCID 0000-0003-3724-9195
Gina C DonofrioHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Ningbo JianHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Hannah A D KingHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Cynthia G LorangVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Elizabeth J MartinezEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.ORCID 0000-0002-7755-7056
Phyllis A ReesEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Caroline E PetersonEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Fabian SchmidtLaboratory of Retrovirology, The Rockefeller University, New York, NY, USA.
Tricia J HartTrudeau Institute, Saranac Lake, NY, USA.
Debra K DusoTrudeau Institute, Saranac Lake, NY, USA.
Lawrence W KummerTrudeau Institute, Saranac Lake, NY, USA.
Sean P CaseyTrudeau Institute, Saranac Lake, NY, USA.
Jazmean K WilliamsIntegral Molecular, Philadelphia, PA, USA.
Shruthi KannanIntegral Molecular, Philadelphia, PA, USA.
Bonnie M SlikeHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.ORCID 0000-0003-4132-4637
Lauren SmithHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Isabella SwaffordHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Paul V ThomasEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Ursula TranHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Jeffrey R CurrierViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Diane L BoltonHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.ORCID 0000-0003-1897-499X
Edgar DavidsonIntegral Molecular, Philadelphia, PA, USA.
Benjamin J DoranzIntegral Molecular, Philadelphia, PA, USA.ORCID 0000-0002-8245-3083
Theodora HatziioannouLaboratory of Retrovirology, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-7889-0766
Paul D BieniaszLaboratory of Retrovirology, The Rockefeller University, New York, NY, USA.
Dominic Paquin-ProulxHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.ORCID 0000-0003-1407-3414
William W ReileyTrudeau Institute, Saranac Lake, NY, USA.
Morgane RollandEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.ORCID 0000-0003-3650-8490
Nancy J SullivanVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Sandhya VasanEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.ORCID 0000-0002-6378-6288
Natalie D CollinsEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Kayvon ModjarradEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Gregory D GromowskiViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.ORCID 0000-0003-4576-4277
Victoria R PolonisU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Nelson L MichaelCenter for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Shelly J KrebsEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA. skrebs@hivresearch.org.ORCID 0000-0003-1136-1760
M Gordon JoyceEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA. gjoyce@eidresearch.org.ORCID 0000-0002-6808-7232
Henry M. Jackson Foundation · USWalter Reed Army Institute of Research · USTrudeau Institute · USIntegral Molecular (United States) · USNational Institutes of Health · USRockefeller University · USHoward Hughes Medical Institute · USPfizer (United States) · US

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI STEVEN E EALICK · 2018 to 2026
$34.2M
Overcoming Host Restriction Factors to Develop Better Animal Models for HIV/AIDS.R01AI078788 · NIAID · ROCKEFELLER UNIVERSITY · PI HATZIIOANNOU, THEODORA · 2008 to 2021
$9.3M
RNA Protein interactions in HIV-1 replicationR01AI050111 · NIAID · ROCKEFELLER UNIVERSITY · PI BIENIASZ, PAUL D. · 2001 to 2021
$7.9M
B-Cell Epitope Discovery and Mechanisms of Antibody Protection for ZIKV, MARV, VEEV Envelope Proteins 75N93019C00073 · NIAID · INTEGRAL MOLECULAR · PI DORANZ, BENJAMIN · 2019 to 2023
$7.5M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
NIAID NIH HHS 75N93019C00073NIAID NIH HHS R01 AI050111NIAID NIH HHS R01 AI078788NIGMS NIH HHS P30 GM124165NIH HHS S10 OD021527
6 · The paper itself

Abstract

The repeat emergence of SARS-CoV-2 variants of concern (VoC) with decreased susceptibility to vaccine-elicited antibodies highlights the need to develop next-generation vaccine candidates that confer broad protection. Here we describe the antibody response induced by the SARS-CoV-2 Spike Ferritin Nanoparticle (SpFN) vaccine candidate adjuvanted with the Army Liposomal Formulation including QS21 (ALFQ) in non-human primates. By isolating and characterizing several monoclonal antibodies directed against the Spike Receptor Binding Domain (RBD), N-Terminal Domain (NTD), or the S2 Domain, we define the molecular recognition of vaccine-elicited cross-reactive monoclonal antibodies (mAbs) elicited by SpFN. We identify six neutralizing antibodies with broad sarbecovirus cross-reactivity that recapitulate serum polyclonal antibody responses. In particular, RBD mAb WRAIR-5001 binds to the conserved cryptic region with high affinity to sarbecovirus clades 1 and 2, including Omicron variants, while mAb WRAIR-5021 offers complete protection from B.1.617.2 (Delta) in a murine challenge study. Our data further highlight the ability of SpFN vaccination to stimulate cross-reactive B cells targeting conserved regions of the Spike with activity against SARS CoV-1 and SARS-CoV-2 variants.

Indexed as

NanoparticlesSevere acute respiratory syndrome-related coronavirusAnimalsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesFerritinsMacaca mulattaMiceSARS-CoV-2Spike Glycoprotein, CoronavirusVaccinationAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesFerritinsSpike Glycoprotein, Coronavirus

Identifiers

PMID38172512
PMCPMC10764318
OpenAlexW4390542348

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.