ArticleNature nanotechnology2024
Nanosensor detection of reactive oxygen and nitrogen species leakage in frustrated phagocytosis of nanofibres.
Article in Nature nanotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Mitochondria-Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA-Driven Inflammation at the Source.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Macrophages bend long fibres with flexural rigidity lower than 3 mN·nmParticle and fibre toxicology · 2026Article
- Airborne particulate matter and the lung-brain axis: unraveling the neuroinflammatory cascade from alveolar irritation to microglial activation.Journal of neuroinflammation · 2026Review
- Polystyrene microplastic-induced pathophysiology is driven by disruption of efferocytosis.Immunity · 2026Article
- Quantification of Single-Cell Cysteine Using an Electrochemical Nanosensor for Predicting Tumor Disulfidptosis Susceptibility.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Hydrogen-bond-assisted meta-nitrogen-doped graphyne enables real-time electrocatalytic NADH tracking in single cells.Chemical science · 2026Article
- Application of nanoparticles in the therapeutic management of endometrial cancer.European journal of medical research · 2026Review
- Interconversions between RNS Revealed by Transient Voltammetry with Porphyrin-Modified Carbon Nanopipettes in Single Living Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Longitudinal transformation of mitochondrial metabolism during neurogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Biopersistence of man-made vitreous fibres (MMVF) / synthetic vitreous fibres (SVF): advancing from animal models to acellular testing.Particle and fibre toxicology · 2025Review
- Nanoparticle-induced systemic toxicity and immune response inFrontiers in pharmacology · 2025Article
- Nanoelectrochemical Monitoring of pH-Regulated Reactive Oxygen and Nitrogen Species Homeostasis in Macrophages Lysosomes during Phagocytosis.Research (Washington, D.C.) · 2025Article
- Bifunctional nanoprobe for simultaneous detection of intracellular reactive oxygen species and temperature in single cells.Microsystems & nanoengineering · 2024Article
- Unlocking the electrochemical functions of biomolecular condensates.Nature chemical biology · 2024Review
- Recent Developments in Single-Entity Electrochemistry.Analytical chemistry · 2024Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Exposure to widely used inert fibrous nanomaterials (for example, glass fibres or carbon nanotubes) may result in asbestos-like lung pathologies, becoming an important environmental and health concern. However, the origin of the pathogenesis of such fibres has not yet been clearly established. Here we report an electrochemical nanosensor that is used to monitor and quantitatively characterize the flux and dynamics of reactive species release during the frustrated phagocytosis of glass nanofibres by single macrophages. We show the existence of an intense prolonged release of reactive oxygen and nitrogen species by single macrophages near their phagocytic cups. This continued massive leakage of reactive oxygen and nitrogen species damages peripheral cells and eventually translates into chronic inflammation and lung injury, as seen during in vitro co-culture and in vivo experiments.
Indexed as
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38172432What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.