Evidence map›Paper›PMID 38172346›Full record

ArticleEuropean journal of clinical nutrition2024

Infant growth and body composition from birth to 24 months: are infants developing the same?

Shane A Norris, Lukhanyo H Nyati, Alexia Murphy-Alford, Nishani Lucas, Ina S Santos, Caroline S Costa, Rebecca Kuriyan, V Pujitha Wickranasinghe, Shabina Ariff, Sisitha Jayasinghe and 4 more

Abstract readMulticenter Study
In one paragraph

Article in European journal of clinical nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shane A NorrisSAMRC Developmental Pathways for Health Research Unit, Department of Pediatrics, University of the Witwatersrand, Johannesburg, South Africa.ORCID http://orcid.org/0000-0001-7124-3788
Lukhanyo H NyatiSAMRC Developmental Pathways for Health Research Unit, Department of Pediatrics, University of the Witwatersrand, Johannesburg, South Africa. lukhanyo.nyati@gmail.com.ORCID http://orcid.org/0000-0003-0975-344X
Alexia Murphy-AlfordInternational Atomic Energy Agency, Vienna, Austria.ORCID http://orcid.org/0000-0001-7095-3796
Nishani LucasDepartment of Paediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.ORCID http://orcid.org/0000-0001-7243-7525
Ina S SantosFederal University of Pelotas, Pelotas, Brazil.ORCID http://orcid.org/0000-0003-1258-9249
Caroline S CostaFederal University of Pelotas, Pelotas, Brazil.
Rebecca KuriyanDivision of Nutrition, St John's Research Institute, Bengaluru, India.ORCID http://orcid.org/0000-0002-3864-574X
V Pujitha WickranasingheDepartment of Paediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Shabina AriffDept Pediatrics & Child Health, The Aga Khan University, Karachi, Pakistan.ORCID http://orcid.org/0000-0002-9627-2662
Sisitha JayasingheUniversity of Tasmania, Hobart, TAS, Australia.ORCID http://orcid.org/0000-0001-8805-385X
Anura V KurpadDivision of Nutrition, St John's Research Institute, Bengaluru, India.ORCID http://orcid.org/0000-0001-7998-2438
Leila Cheikh IsmailUniversity of Sharjah, Sharjah, United Arab Emirates.
Andrew P HillsUniversity of Tasmania, Hobart, TAS, Australia.ORCID http://orcid.org/0000-0002-7787-7201
Multi-center Infant Body Composition Reference Study (MIBCRS)

Funding

International Atomic Energy Agency (IAEA) CRP E43028
6 · The paper itself

Abstract

backgroundGiven the importance of infancy for establishing growth trajectories, with later-life health consequences, we investigated longitudinal body composition among infants from six economically and ethnically diverse countries.

methodsWe recruited mother-infant dyads using the WHO Multicenter Growth Reference Study criteria. We measured fat-free mass (FFM) in 1393 (49% female) infants from birth to 6 months of age (Australia, India, and South Africa; n = 468), 3-24 months of age (Brazil, Pakistan, South Africa, and Sri Lanka; n = 925), and derived fat mass (FM), fat mass index (FMI), and fat-free mass index (FFMI). Height-for-age (HAZ), weight-for-age (WAZ), and weight-for-length (WHZ) Z-scores were computed. Sex differences were assessed using a t-test, and country differences using a one-way analysis of covariance. We further compared subsamples of children with average (-0.25 > HAZ < +0.25), below-average (≤-0.25) and above-average (≥+0.25) HAZ.

resultsHAZ performed well between 0 and 6 months, but less so between 3 and 24 months. The stunting prevalence peaked at 10.3% for boys and 7.8% for girls, at 24 months. By 24 months, girls had greater FMI (10%) than boys. There were significant differences in FFM (both sexes in all countries) and FM (Brazilian boys, Pakistani and South African girls) by 24 months of age between infants with average, above-average, and below-average HAZ.

conclusionIn a multi-country sample representing more ideal maternal conditions, body composition was heterogeneous even among infants who exhibited ideal length. Having a mean HAZ close to the median of the WHO standard for length reduced FFM between-country heterogeneity but not FM, suggesting that other factors may influence adiposity.

Indexed as

Body CompositionBody HeightChild DevelopmentAustraliaBody WeightBrazilChild, PreschoolFemaleHumansIndiaInfantInfant, NewbornLongitudinal StudiesMalePakistanSex Factors

Identifiers

PMID38172346
PMCPMC11537950

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.