Evidence map›Paper›PMID 38172261›Full record

ArticleClinical neuroradiology2024

Establishing Optic Nerve Diameter Threshold Sensitive and Specific for Optic Atrophy Diagnosis.

Michael L Prairie, Mehmet Gencturk, Collin M McClelland, Nicholas A Marka, Ziou Jiang, Mark Folkertsma, Michael S Lee

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In one paragraph

Article in Clinical neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michael L PrairieDepartments of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-4663-6640
Mehmet GencturkDepartment of Neuroradiology, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-5980-5637
Collin M McClellandDepartments of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0003-2836-4263
Nicholas A MarkaDepartment of Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-9306-5505
Ziou JiangDepartment of Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-4063-5671
Mark FolkertsmaDepartment of Neuroradiology, University of Minnesota, Minneapolis, MN, USA.
Michael S LeeDepartments of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA. mikelee@umn.edu.ORCID http://orcid.org/0000-0003-2691-4532

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
NCATS NIH HHS UL1-TR002494
6 · The paper itself

Abstract

purposeTo determine a potential threshold optic nerve diameter (OND) that could reliably differentiate healthy nerves from those affected by optic atrophy (OA) and to determine correlations of OND in OA with retinal nerve fiber layer (RNFL) thickness, visual acuity (VA), and visual field mean deviation (VFMD).

methodsThis was a retrospective case control study. Magnetic resonance (MR) images were reviewed from individuals with OA aged 18 years or older with vision loss for more than 6 months and an OA diagnosis established by a neuro-ophthalmologist. Individuals without OA who underwent MR imaging of the orbit for other purposes were also collected. OND was measured on coronal T2-weighted images in the midorbital section, 1cm posterior to the optic disc. Measurements of mean RNFL thickness, VA and VFMD were also collected.

resultsIn this study 47 OA subjects (63% women, 78 eyes) and 75 normal subjects (42.7% women, 127 eyes) were assessed. Healthy ONDs (mean 2.73 ± 0.24 mm) were significantly greater than OA nerve diameters (mean 1.94 ± 0.32 mm; P < 0.001). A threshold OND of ≤2.3 mm had a sensitivity of 0.92 and a specificity of 0.93 in predicting OA. Mean RNFL (r = 0.05, p = 0.68), VA (r = 0.17, p = 0.14), and VFMD (r = 0.18, p = 0.16) were not significantly associated with OND.

conclusionONDs are significantly reduced in patients with OA compared with healthy nerves. A threshold OND of ≤2.3 mm is highly sensitive and specific for a diagnosis of OA. OND was not significantly correlated with RNFL thickness, VA, or VFMD.

Indexed as

Magnetic Resonance ImagingOptic AtrophyOptic NerveSensitivity and SpecificityAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedReproducibility of ResultsRetrospective StudiesVisual AcuityLongstandingMRINeuro-ophthalmologyOptic atrophyOptic nerve imagingOrbitRetinal nerve fiber layer

Identifiers

PMID38172261

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.