ArticleNature immunology2024
GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- Article
- Senescent-Like Neutrophils Shape Angiogenic Immunosuppressive Niches in Colorectal Cancer Liver Metastasis.Cancer discovery · 2026Article
- Genetic testing in liver diseases: Clinical applications.JHEP reports : innovation in hepatology · 2026Review
- Synergy between upregulated small GTPase immunity-associated proteins and lysosomal ATP6V1D in restricting intracellularMicrobiology spectrum · 2026Article
- Lifespan-Extending Endogenous Metabolites.Aging cell · 2026Review
- Predictive and mechanistic insights ofPeerJ · 2026Article
- Unexpected genetically determined immune dysregulation with liver involvement: GIMAP5 therapeutic dilemmas between targeted therapy and HSCT.Frontiers in immunology · 2026Article
- Quantitative temporal analysis of pancreatic islet T lymphocyte and macrophage infiltration heralded by serum IgE in congenic BioBreeding (BB) Gimap5Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Targeting T-cell Aging to Remodel the Aging Immune System and Revitalize Geriatric Immunotherapy.Aging and disease · 2025Review
- Genetic Evaluation of the Patients with Clinically Diagnosed Inborn Errors of Immunity by Whole Exome Sequencing: Results from a Specialized Research Center for Immunodeficiency in Türkiye.Journal of clinical immunology · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
74 authors at 18 institutions in 6 countries.
Ann Y Park *Molecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-0130-1521
Michael Leney-Greene *Molecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Matthew LynbergMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Justin Q GabrielskiMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-2953-2874
Xijin XuMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Benjamin SchwarzLaboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Lixin ZhengMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Arasu BalasubramaniyamMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Hyoungjun HamClinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-8669-6875
Brittany ChaoMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Yu ZhangClinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Helen F MatthewsMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Jing CuiMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Yikun YaoMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Satoshi KuboMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-9693-9263
Jean Michel ChanchuMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0009-0009-8024-8412
Aaron R MorawskiMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-5995-0527
Sarah A CookMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Ping JiangMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Juan C RavellMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Yan H ChengMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Alex GeorgeMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Aiman FaruqiMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-4421-3767
Alison M PagalilauanMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Jenna R E BergersonLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Sundar GanesanBiological Imaging Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Samuel D ChauvinMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-0232-751X
Jahnavi AluriMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Joy Edwards-HicksDepartment of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Eric BohrnsenLaboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Caroline TippettSection of Digestive Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Habib OmarMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Leilei XuMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Geoffrey W ButcherLaboratory of Lymphocyte Signaling and Development, The Babraham Institute, Cambridge, United Kingdom.
John PascallLaboratory of Lymphocyte Signaling and Development, The Babraham Institute, Cambridge, United Kingdom.
Elif Karakoc-AydinerDivision of Pediatric Allergy and Immunology, Marmara University, School of Medicine Pendik, Istanbul, Turkey.
Ayca KiykimDivision of Pediatric Allergy and Immunology, Marmara University, School of Medicine Pendik, Istanbul, Turkey.
Holden MaeckerInstitute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0003-0795-9946
İlhan TezcanDepartment of Pediatrics, Division of Pediatric Immunology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
Saliha EsenbogaDepartment of Pediatrics, Division of Pediatric Immunology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
Raul Jimenez HerediaSt Anna Children's Cancer Research Institute, Vienna, Austria.
Deniz AkataDepartment of Radiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Saban TekinDepartment of Basic Medical Sciences, Hamidiye Faculty of Medicine, Division of Medical Biology, University of Health Sciences, İstanbul, Turkey.ORCID http://orcid.org/0000-0003-2641-6293
Altan KaraTUBITAK Marmara Research Center, Gene Engineering and Biotechnology Institute, Gebze, Turkey.ORCID http://orcid.org/0000-0001-7244-5031
Zarife KulogluDepartment of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Ankara University School of Medicine, Ankara, Türkiye.
Emel UnalDepartment of Pediatric Oncology, Ankara University Medical School, Ankara, Turkey.
Tanıl KendirliDepartment of Pediatric Intensive Care Unit, Ankara University Medical School, Ankara, Turkey.
Figen DoguDepartment of Pediatric Immunology and Allergy, Ankara University Medical School, Ankara, Turkey.
Esra KarabiberDepartment of Chest Diseases, Faculty of Medicine, Division of Adult Allergy-Immunology, Marmara University, Istanbul, Turkey.
T Prescott AtkinsonDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Claude CochetUniversity Grenoble Alpes, INSERM, CEA, UMR Biosanté, Grenoble, France.
Odile FilholUniversity Grenoble Alpes, INSERM, CEA, UMR Biosanté, Grenoble, France.ORCID http://orcid.org/0000-0003-1964-7958
Catherine M BosioLaboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Mark M DavisInstitute for Immunity, Transplantation and Infection, Stanford University, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0001-6868-657X
Richard P LiftonDepartment of Genetics, Yale School of Medicine, Yale University, New Haven, CT, USA.
Erika L PearceDepartment of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.ORCID http://orcid.org/0000-0001-5592-5439
Oliver DaumkeDepartment of Structural Biology, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.ORCID http://orcid.org/0000-0002-6190-1414
Caner AytekinDepartment of Pediatric Immunology, Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.ORCID http://orcid.org/0000-0002-2921-5270
Gülseren Evirgen ŞahinDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, University of Health Sciences, Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
Aysel Ünlüsoy AksuDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, University of Health Sciences, Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
Gulbu UzelLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
V Koneti RaoLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-7881-6902
Sinan SariDepartment of Pediatric Gastroenterology, Gazi University Faculty of Medicine, Ankara, Turkey.
Buket DalgıçDepartment of Pediatric Gastroenterology, Gazi University Faculty of Medicine, Ankara, Turkey.
Kaan BoztugSt Anna Children's Cancer Research Institute, Vienna, Austria.
Deniz CagdasDepartment of Pediatrics, Division of Pediatric Immunology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
Sule HaskologluDepartment of Pediatric Immunology and Allergy, Ankara University Medical School, Ankara, Turkey.ORCID http://orcid.org/0000-0002-2668-0441
Aydan IkinciogullariDepartment of Pediatric Immunology and Allergy, Ankara University Medical School, Ankara, Turkey.
David SchwefelDepartment of Structural Biology, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Silvia VilarinhoSection of Digestive Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Safa BarisDivision of Pediatric Allergy and Immunology, Marmara University, School of Medicine Pendik, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-4730-9422
Ahmet OzenDivision of Pediatric Allergy and Immunology, Marmara University, School of Medicine Pendik, Istanbul, Turkey.
Helen C SuClinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-5582-9110
Michael J LenardoMolecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. lenardo@nih.gov.ORCID http://orcid.org/0000-0003-1584-468X
National Institutes of Health · USAnkara University · TRMarmara University · TRHacettepe University · TRMinistry of Health · TRYale University · USBabraham Institute · GBGazi University · TRInserm · FRMax Delbrück Center · DEStanford University · USAustrian Academy of Sciences · ATBloomberg (United States) · USMax Planck Institute of Immunobiology and Epigenetics · DESağlık Bilimleri Üniversitesi · TRSt Anna Children's Hospital · ATTÜBİTAK Marmara Research Center · TRUniversity of Alabama at Birmingham · US
Funding
Infectious Diseases Research Technologies Core - BethesdaZICAI001051 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CHERRY, JAMES · 2009 to 2025
$226.1MDefining New Human Immunodeficiency and Immunodysregulation DisordersZIAAI001059 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SU, HELEN CHUN-HUI · 2009 to 2025
$20.5MImmunity to Pulmonary InfectionsZIAAI001013 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BOSIO, CATHARINE · 2009 to 2025
$18.9MThe effects of immune-age on immune-response and the molecular mechanisms which drive itP01AI153559 · NIAID · STANFORD UNIVERSITY · PI SHEN-ORR, SHAI SHLOMO · 2021 to 2025
$17.8MMolecular Mechanisms Of The Autoimmune Lymphoproliferative Syndrome And Other Immunoregulatory DisordersZIAAI000769 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SU, HELEN · 2009 to 2024
$16.7MClinical, Immunological and Genetic Analyses of ALPS and Related Immunedysregulatory DisordersZIAAI000732 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI RAO, V KONETI · 2009 to 2025
$10.5MLiver Pathobiology: insights through the lens of rare diseasesR01DK131033 · NIDDK · YALE UNIVERSITY · PI Silvia Vilarinho · 2022 to 2026
$2.4MDeciphering the Genetic Basis of Portal HypertensionK08DK113109 · NIDDK · YALE UNIVERSITY · PI VILARINHO, SILVIA · 2018 to 2022
$851kBiotechnology and Biological Sciences Research Council BBS/E/B/000C0407Intramural NIH HHS ZIA AI000769NIAID NIH HHS P01 AI153559NIDDK NIH HHS K08 DK113109NIDDK NIH HHS R01 DK131033
Abstract
Preserving cells in a functional, non-senescent state is a major goal for extending human healthspans. Model organisms reveal that longevity and senescence are genetically controlled, but how genes control longevity in different mammalian tissues is unknown. Here, we report a new human genetic disease that causes cell senescence, liver and immune dysfunction, and early mortality that results from deficiency of GIMAP5, an evolutionarily conserved GTPase selectively expressed in lymphocytes and endothelial cells. We show that GIMAP5 restricts the pathological accumulation of long-chain ceramides (CERs), thereby regulating longevity. GIMAP5 controls CER abundance by interacting with protein kinase CK2 (CK2), attenuating its ability to activate CER synthases. Inhibition of CK2 and CER synthase rescues GIMAP5-deficient T cells by preventing CER overaccumulation and cell deterioration. Thus, GIMAP5 controls longevity assurance pathways crucial for immune function and healthspan in mammals.
Indexed as
CeramidesGTP-Binding ProteinsAnimalsEndothelial CellsHumansLongevityMammalsCeramidesGTP-Binding Proteins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.