ArticleNature communications2024
Surface hydrophobization of hydrogels via interface dynamics-induced network reconfiguration.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
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Who cites it
22 citing papers in PubMed.
- Water-responsive injectable hydrogel achieving rapid in situ gelation and long-term colonic mucoadhesion for efficient fecal microbiota transplantation.Bioactive materials · 2027Article
- Engineering Injectable Co-Assembled Hyaluronic Acid-Based Hydrogel by Photothermal Driven Recombinant Human Type III Collagen-Stabilized MoSSmall (Weinheim an der Bergstrasse, Germany) · 2026Article
- Next-Generation Hydrogel Skin Adhesives: From Bioinspired Adhesion Chemistry to Regenerative Wound Interfaces.Advanced healthcare materials · 2026Review
- Recent Advances in Biomimetic Hydrogels for Bioelectronics and Human-Machine Interactions.Gels (Basel, Switzerland) · 2026Review
- Thermodynamics of Interfacial Water Confinement Reveal Altered Mechanical Properties in Polysaccharides Films.ACS polymers Au · 2026Article
- Anti-Swelling Hydrogel Wearable Sensors: Structural Engineering, Internal Water Environment Regulation, and Motion Monitoring in Complex Environments.Gels (Basel, Switzerland) · 2026Review
- Superspreading and ultra-infiltrative coacervate mediates strong underwater adhesion on hydrated and lipidic substrates.Nature chemistry · 2026Article
- Oligomeric-solvent engineering of hierarchical hydrogen-bonding networks for multifunctional glass interlayers.Nature communications · 2026Article
- A dynamically adaptive wet-adhesive Janus hydrogel patch for sutureless repair of spinal dural defects.Bioactive materials · 2026Article
- Bionic Janus hydrogel drives infected Achilles tendon regeneration via mechano-immune spatiotemporal steering.Nature communications · 2026Article
- A review on thermoresponsive PNIPAM hydrogels for regenerative medicine: from mechanical design to tissue adhesion.Regenerative biomaterials · 2026Review
- Cocklebur-inspired magnetic nanomotors for targeted thrombus therapy.Bioactive materials · 2026Article
- Biomimetic hydrogel micro-/nanofibers forBioactive materials · 2026Review
- A Biomass-Inspired Hydrogel Patch for Intelligent Pain Monitoring and On-Demand Analgesia.Research (Washington, D.C.) · 2026Article
- Hydrogel-based systems with nanoparticle and microencapsulation for food preservation: Preparation, characterization, and application.Food chemistry: X · 2026Review
- Robust and ultra-stable nanohesive-based solid-like slippery coating under dynamic blood flow environment for durable prevention of thrombosis and biofouling.Materials today. Bio · 2025Article
- Article
- Mucus-Inspired Supramolecular Adhesives: Exploring the Synergy between Dynamic Networks and Functional Liquids.ACS nano · 2025Review
- Molecular Dynamics Simulation of Structural Assembly and Hydration of Hyaluronic Acid in Salt Aqueous Buffer.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Emerging novel hydrogels application in oral and gastrointestinal diseases: design wet adhesive strategy towards possible mechanisms.Science and technology of advanced materials · 2025Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effective and easy regulation of hydrogel surface properties without changing the overall chemical composition is important for their diverse applications but remains challenging to achieve. We report a generalizable strategy to reconfigure hydrogel surface networks based on hydrogel-substrate interface dynamics for manipulation of hydrogel surface wettability and bioadhesion. We show that the grafting of hydrophobic yet flexible polymeric chains on mold substrates can significantly elevate the content of hydrophobic polymer backbones and reduce the presence of polar groups in hydrogel surface networks, thereby transforming the otherwise hydrophilic hydrogel surface into a hydrophobic surface. Experimental results show that the grafted highly dynamic hydrophobic chains achieved with optimal grafting density, chain length, and chain structure are critical for such substantial hydrogel surface network reconfiguration. Molecular dynamics simulations further reveal the atomistic details of the hydrogel network reconfiguration induced by the dynamic interface interactions. The hydrogels prepared using our strategy show substantially enhanced bioadhesion and transdermal delivery compared with the hydrogels of the same chemical composition but fabricated via the conventional method. Our findings provide important insights into the dynamic hydrogel-substrate interactions and are instrumental to the preparation of hydrogels with custom surface properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.