HIV-associated CD8+ T-cell Skin Infiltrative Disease and EBV-associated Polymorphic B-cell Lymphoproliferative Disorder in an AIDS Patient Who Improved Dramatically with Antiretroviral Therapy Alone.

Naoki Okada, Kenki Saito, Momoko Watanabe, Toshio Ohtani, Kenji Notohara, Hideho Wada, Yasunori Ueda

Abstract readCase Reports

In one paragraph

Article in Internal medicine (Tokyo, Japan), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Naoki OkadaDepartment of Hematology/Oncology, Kurashiki Central Hospital, Japan.

Kenki SaitoDepartment of Hematology/Oncology, Kurashiki Central Hospital, Japan.

Momoko WatanabeDepartment of Dermatology, Kurashiki Central Hospital, Japan.

Toshio OhtaniDepartment of Dermatology, Kurashiki Central Hospital, Japan.

Kenji NotoharaDepartment of Anatomic Pathology, Kurashiki Central Hospital, Japan.

Hideho WadaDepartment of Hematology, Kawasaki Medical School, Japan.

Yasunori UedaDepartment of Hematology/Oncology, Kurashiki Central Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human immunodeficiency virus (HIV)-associated CD8+ T-cell skin infiltrative disease with severe erythroderma has rarely been reported. While HIV-positive patients are prone to develop lymphoma, which is often associated with Epstein-Barr virus, polymorphic lymphoproliferative disorder is rare, accounting for <5% of cases. We herein report a 41-year-old HIV-positive man who presented with a fever, erythroderma, and lymphadenopathy and was diagnosed with the coexistence of both diseases. His condition improved significantly with continued antiretroviral therapy. This case suggests that HIV-induced immunodeficiency is central to the pathogenesis of both entities and that improvement of the immunodeficient state is an effective treatment.

Indexed as

CD8-Positive T-LymphocytesEpstein-Barr Virus InfectionsLymphoproliferative DisordersAcquired Immunodeficiency SyndromeAdultAntiretroviral Therapy, Highly ActiveB-LymphocytesHerpesvirus 4, HumanHIV InfectionsHumansMaleTreatment Outcomeantiretroviral therapyEBV-associated polymorphic B-cell lymphoproliferative disordererythrodermaHIV-associated CD8+ T-cell skin infiltrative disease

Identifiers

PMID38171853

DOI10.2169/internalmedicine.2687-23

PMCPMC11358741

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