ArticleJournal of clinical neurology (Seoul, Korea)2024
Lower-Body Fractures and the Risk of Dementia: A Nationwide Population-Based Study.
Article in Journal of clinical neurology (Seoul, Korea), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Comorbidity Trajectories Before and After Hip Fracture in Elderly Patients: A Korean Nationwide Database Cohort Study.Journal of Korean medical science · 2026Article
- The association of hemorrhoids with the incidence of heart failure: a nationwide cohort study.Annals of translational medicine · 2025Article
- Association between varicose veins and occurrence of dementia: A nationwide population-based cohort study.PloS one · 2025Article
- Association of renal hyperfiltration with incidence of dyslipidemia: a nationwide retrospective longitudinal cohort study.PloS one · 2025Article
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Authors and funding
8 authors.
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Abstract
background and purposeThe association between physical activity and dementia has been shown in various observational studies. We aimed to determine the risk of dementia in the elderly with lower-body fractures.
methodsWe reconstructed a population-based matched cohort from the National Health Insurance Service-Senior Cohort data set that covers 511,953 recipients of medical insurance in South Korea.
resultsOverall 53,776 subjects with lower-body fractures were identified during 2006-2012, and triplicate control groups were matched randomly by sex, age, and years from the index date for each subject with a fracture. There were 3,573 subjects (6.6%) with and 7,987 subjects (4.9%) without lower-body fractures who developed dementia from 2008 up to 2015. Lower-body fractures were independently associated with a subsequent dementia diagnosis with a higher adjusted hazard ratio (aHR) (1.55, 95% confidence interval [CI]=1.49-1.62) compared with upper-body fractures (aHR=1.19, 95% CI=1.14-1.23).
conclusionsThese results support the protective role of physical activity against dementia and highlight the importance of promoting fracture prevention in the elderly.
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