Evidence map›Paper›PMID 38170993›Full record

ArticlemBio2024

Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through

Chad H Hogan, Shana M Owens, Glennys V Reynoso, Yifei Liao, Thomas J Meyer, Monika A Zelazowska, Bin Liu, Xiaofan Li, Anna K Grosskopf, Camille Khairallah and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. The regulatory roles of STAT3 protein in the pathogenesis of viral infections.Frontiers in cellular and infection microbiology · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 1 country.

Chad H HoganGraduate Program in Genetics, Stony Brook University, Stony Brook, New York, USA.
Shana M OwensDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Glennys V ReynosoViral Immunity and Pathogenesis Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
Yifei LiaoDivision of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Thomas J MeyerCCR Collaborative Bioinformatics Resource, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Monika A ZelazowskaDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Bin LiuDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Xiaofan LiHIV & AIDS Malignancy Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA.
Anna K GrosskopfHIV & AIDS Malignancy Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA.ORCID 0000-0001-5814-1349
Camille KhairallahDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
Varvara KirillovDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
Nancy C ReichDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
Brian S SheridanDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
Kevin M McBrideDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0001-9646-152X
Benjamin E GewurzDivision of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Heather D HickmanViral Immunity and Pathogenesis Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.ORCID 0000-0003-4168-4894
J Craig ForrestDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Laurie T KrugHIV & AIDS Malignancy Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA.ORCID 0000-0002-9648-522X
Stony Brook School · USNational Cancer Institute · USThe University of Texas MD Anderson Cancer Center · USNational Institute of Allergy and Infectious Diseases · USUniversity of Arkansas for Medical Sciences · USBrigham and Women's Hospital · USBroad Institute · USNational Institutes of Health · US

Funding

CCR Collaborative Bioinformatics ResourceZICBC011532 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MALIK, MARIAM · 2013 to 2025
$33.7M
Imaging Antiviral ImmunityZIAAI001225 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HICKMAN, HEATHER · 2017 to 2025
$11.4M
Investigation of viral and host determinants of gammaherpesvirus pathogenesisZIABC011953 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KRUG, LAURIE TATE · 2020 to 2025
$8.1M
B cell determinants of EBV latency (supplement)U01CA275301 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Ethel Cesarman, Benjamin Elison Gewurz · 2022 to 2026
$4.0M
Gammaherpesvirus interactions with host tumor suppressor p53R01CA167065 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI James Craig Forrest · 2014 to 2026
$3.8M
Epstein-Barr virus LMP1 mediated oncogenicityR01CA228700 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI Benjamin Elison Gewurz · 2019 to 2026
$3.3M
Regulation of the Epstein-Barr Virus Lytic SwitchR01AI164709 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Benjamin Elison Gewurz · 2021 to 2026
$3.1M
Uracil DNA Glycosylases in Gammaherpesvirus Pathogenesis and B Cell DevelopmentR01AI125397 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MCBRIDE, KEVIN MICHAEL · 2016 to 2020
$2.4M
Functional Analysis of STAT3 in Gammaherpesvirus InfectionR01AI119079 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI REICH MARSHALL, NANCY C. · 2015 to 2019
$2.2M
J. NRSA TrainingTL1TR003109 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI SEXTON, KEVIN WAYNE · 2019 to 2023
$1.5M
Defining the efficacy of replication-dead viruses as gammaherpesvirus vaccinesR21AI139580 · NIAID · UNIV OF ARKANSAS FOR MED SCIS · PI FORREST, JAMES CRAIG · 2019 to 2020
$440k
NCATS NIH HHS TL1 TR003109NCI NIH HHS R01 CA167065NCI NIH HHS R01 CA228700NCI NIH HHS U01 CA275301NIAID NIH HHS R01 AI119079NIAID NIH HHS R01 AI125397NIAID NIH HHS R01 AI164709NIAID NIH HHS R21 AI139580
6 · The paper itself

Abstract

Cancers associated with the oncogenic gammaherpesviruses, Epstein-Barr virus and Kaposi sarcoma herpesvirus, are notable for their constitutive activation of the transcription factor signal transducer and activator of transcription 3 (STAT3). To better understand the role of STAT3 during gammaherpesvirus latency and the B cell response to infection, we used the model pathogen murine gammaherpesvirus 68 (MHV68). Genetic deletion of STAT3 in B cells of

Indexed as

Epstein-Barr Virus InfectionsGammaherpesvirinaeHerpesviridae InfectionsHerpesvirus 8, HumanRhadinovirusSarcoma, KaposiAnimalsHerpesvirus 4, HumanHumansMiceMice, Inbred C57BLSTAT3 Transcription FactorVirus LatencySTAT3 protein, humanStat3 protein, mouseSTAT3 Transcription Factorgammaherpesvirushost-pathogen interactionshuman herpesvirusesKaposi sarcoma-associated herpesviruslatent infectionSTAT transcription factors

Identifiers

PMID38170993
PMCPMC10870824
OpenAlexW4390532460

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.