Evidence map›Paper›PMID 38170904›Full record

ArticleJournal of the American Chemical Society2024

MYC-Targeting Inhibitors Generated from a Stereodiversified Bicyclic Peptide Library.

Zhonghan Li, Yi Huang, Ta I Hung, Jianan Sun, Desiree Aispuro, Boxi Chen, Nathan Guevara, Fei Ji, Xu Cong, Lingchao Zhu and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Targeting MYC-Driven Cancers: From Oncogenic Addiction to Therapeutic Vulnerability.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Zhonghan LiDepartment of Chemistry, University of California, Riverside, Riverside, California 92521, United States.ORCID 0000-0002-8362-5617
Yi HuangDepartment of Chemistry, University of California, Riverside, Riverside, California 92521, United States.
Ta I HungDepartment of Chemistry, University of California, Riverside, Riverside, California 92521, United States.
Jianan SunEnvironmental Toxicology Graduate Program, University of California, Riverside, Riverside, California 92521, United States.
Desiree AispuroEnvironmental Toxicology Graduate Program, University of California, Riverside, Riverside, California 92521, United States.
Boxi ChenDepartment of Chemistry, University of California, Riverside, Riverside, California 92521, United States.
Nathan GuevaraDepartment of Chemistry, University of California, Riverside, Riverside, California 92521, United States.
Fei JiDepartment of Chemistry, University of California, Riverside, Riverside, California 92521, United States.
Xu CongDepartment of Chemistry, University of California, Riverside, Riverside, California 92521, United States.
Lingchao ZhuDepartment of Chemistry, University of California, Riverside, Riverside, California 92521, United States.
Siwen WangEnvironmental Toxicology Graduate Program, University of California, Riverside, Riverside, California 92521, United States.
Zhili GuoDepartment of Chemistry, University of California, Riverside, Riverside, California 92521, United States.
Chia-En ChangDepartment of Chemistry, University of California, Riverside, Riverside, California 92521, United States.ORCID 0000-0002-6504-8529
Min XueDepartment of Chemistry, University of California, Riverside, Riverside, California 92521, United States.ORCID 0000-0002-8136-6551
University of California, Riverside · US

Funding

Research Training in Environmental ToxicologyT32ES018827 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Yinsheng Wang · 2010 to 2026
$5.3M
Next-Generation GPU Computing Resource for Simulating Ligand-Protein Binding Kinetics/MechanismR01GM109045 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI CHANG, CHIA-EN · 2014 to 2023
$2.8M
Interrogation and interpretation of protein kinase signaling dynamics at single-cell resolutionR35GM138214 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Min Xue · 2020 to 2026
$2.2M
NIEHS NIH HHS T32 ES018827NIGMS NIH HHS R01 GM109045NIGMS NIH HHS R35 GM138214
6 · The paper itself

Abstract

Here, we present the second generation of our bicyclic peptide library (NTB), featuring a stereodiversified structure and a simplified construction strategy. We utilized a tandem ring-opening metathesis and ring-closing metathesis reaction (ROM-RCM) to cyclize the linear peptide library in a single step, representing the first reported instance of this reaction being applied to the preparation of macrocyclic peptides. Moreover, the resulting bicyclic peptide can be easily linearized for MS/MS sequencing with a one-step deallylation process. We employed this library to screen against the E

Indexed as

Peptide LibraryTandem Mass SpectrometryPeptidesPeptide LibraryPeptides

Identifiers

PMID38170904
PMCPMC10797614
OpenAlexW4390534872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.