Evidence map›Paper›PMID 38170788›Full record

ArticleScience translational medicine2024

NAD

Atika Malique, Shengxiang Sun, Kanta Chandwe, Beatrice Amadi, Talin Haritunians, Umang Jain, Brian D Muegge, Jennifer Frein, Yo Sasaki, Amanda Foster and 7 more

Open access · greenAbstract read
In one paragraph

Article in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 3 countries.

Atika MaliqueDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0009-0007-1567-4154
Shengxiang SunDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0001-5889-3292
Kanta ChandweTropical Gastroenterology and Nutrition Group, Department of Medicine, University of Zambia School of Medicine, P.O. Box 50398, Lusaka, Zambia.ORCID 0000-0003-1403-8432
Beatrice AmadiTropical Gastroenterology and Nutrition Group, Department of Medicine, University of Zambia School of Medicine, P.O. Box 50398, Lusaka, Zambia.ORCID 0000-0001-6363-2943
Talin HarituniansF. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID 0000-0002-9005-7750
Umang JainDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0002-0220-8230
Brian D MueggeDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0002-0044-3704
Jennifer FreinDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0009-0006-1177-0897
Yo SasakiDepartment of Genetics, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0003-0024-0031
Amanda FosterDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Chad E StorerDepartment of Genetics, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0002-0139-0819
Emebet MengeshaF. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID 0000-0001-7830-1557
Justin KernDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Dermot P B McGovernF. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Richard D HeadDepartment of Genetics, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Paul KellyTropical Gastroenterology and Nutrition Group, Department of Medicine, University of Zambia School of Medicine, P.O. Box 50398, Lusaka, Zambia.ORCID 0000-0003-0844-6448
Ta-Chiang LiuDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0002-2800-9360
Washington University in St. Louis · USCedars-Sinai Medical Center · USUniversity of Zambia · ZMQueen Mary University of London · GB

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8M
Utilizing the Phenomics of IBD to Enhance Gene DiscoveryU01DK062413 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Dermot Patrick McGovern · 2002 to 2026
$12.2M
Dietary modulation of Paneth cellsR01DK136829 · NIDDK · WASHINGTON UNIVERSITY · PI Ta-Chiang Liu · 2023 to 2026
$2.1M
Paneth cell phenotype as a predictive biomarker for ulcerative colitisR01DK124274 · NIDDK · WASHINGTON UNIVERSITY · PI LIU, TA-CHIANG · 2020 to 2023
$1.5M
Cellular and molecular mechanisms of cigarette smoking-induced Paneth cell abnormalityR01DK125296 · NIDDK · WASHINGTON UNIVERSITY · PI LIU, TA-CHIANG · 2020 to 2023
$1.4M
BLRD VA IK2 BX004909NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NIDDK NIH HHS DK062413NIDDK NIH HHS P30 DK052574NIDDK NIH HHS R01 DK124274NIDDK NIH HHS R01 DK125296NIDDK NIH HHS R01 DK125296, R01 DK124274, AND R01 DK136829NIDDK NIH HHS R01 DK136829NIDDK NIH HHS U01 DK062413
6 · The paper itself

Abstract

Environmental enteric dysfunction (EED) is a diffuse small bowel disorder associated with poor growth, inadequate responses to oral vaccines, and nutrient malabsorption in millions of children worldwide. We identify loss of the small intestinal Paneth and goblet cells that are critical for innate immunity, reduced villous height, increased bile acids, and dysregulated nicotinamide adenine dinucleotide (NAD

Indexed as

Bile Acids and SaltsNADAnimalsChildCytokinesHumansMiceBile Acids and SaltsCytokinesNAD

Identifiers

PMID38170788
PMCPMC12321318
OpenAlexW4390534091

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.