Evidence map›Paper›PMID 38170734›Full record

ArticlePLoS pathogens2024

Fungal chitin-binding glycoprotein induces Dectin-2-mediated allergic airway inflammation synergistically with chitin.

Yasunori Muraosa, Yutaro Hino, Shogo Takatsuka, Akira Watanabe, Emiko Sakaida, Shinobu Saijo, Yoshitsugu Miyazaki, Sho Yamasaki, Katsuhiko Kamei

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS pathogens, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Recent developments inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  2. Review
  3. Effects of Different Defatting Methods of Black Soldier Fly (Animals : an open access journal from MDPI · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Yasunori MuraosaDivision of Clinical Research, Medical Mycology Research Center, Chiba University, Chiba, Japan.ORCID 0000-0002-6979-3921
Yutaro HinoDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Shogo TakatsukaDepartment of Fungal Infection, National Institute of Infectious Diseases, Tokyo, Japan.
Akira WatanabeDivision of Clinical Research, Medical Mycology Research Center, Chiba University, Chiba, Japan.
Emiko SakaidaDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Shinobu SaijoDivision of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chiba, Japan.
Yoshitsugu MiyazakiDepartment of Fungal Infection, National Institute of Infectious Diseases, Tokyo, Japan.
Sho YamasakiDivision of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chiba, Japan.
Katsuhiko KameiDivision of Clinical Research, Medical Mycology Research Center, Chiba University, Chiba, Japan.
Chiba University Hospital · JPNational Institute of Infectious Diseases · JPChiba University · JPKyushu University · JP

Funding

Japan Agency for Medical Research and Development (AMED)JSPS KAKENHI
6 · The paper itself

Abstract

Although chitin in fungal cell walls is associated with allergic airway inflammation, the precise mechanism underlying this association has yet to be elucidated. Here, we investigated the involvement of fungal chitin-binding protein and chitin in allergic airway inflammation. Recombinant Aspergillus fumigatus LdpA (rLdpA) expressed in Pichia pastoris was shown to be an O-linked glycoprotein containing terminal α-mannose residues recognized by the host C-type lectin receptor, Dectin-2. Chitin particles were shown to induce acute neutrophilic airway inflammation mediated release of interleukin-1α (IL-1α) associated with cell death. Furthermore, rLdpA-Dectin-2 interaction was shown to promote phagocytosis of rLdpA-chitin complex and activation of mouse bone marrow-derived dendritic cells (BMDCs). Moreover, we showed that rLdpA potently induced T helper 2 (Th2)-driven allergic airway inflammation synergistically with chitin, and Dectin-2 deficiency attenuated the rLdpA-chitin complex-induced immune response in vivo. In addition, we showed that serum LdpA-specific immunoglobulin levels were elevated in patients with pulmonary aspergillosis.

Indexed as

ChitinLectins, C-TypeAnimalsAspergillus fumigatusGlycoproteinsHumansInflammationMicePhagocytosisChitindectin-2, mouseGlycoproteinsLectins, C-Type

Identifiers

PMID38170734
PMCPMC10763971
OpenAlexW4390571988

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.