Evidence map›Paper›PMID 38170320›Full record

ArticlePsychopharmacology2024

Mice with an autism-associated R451C mutation in neuroligin-3 show intact attention orienting but atypical responses to methylphenidate and atomoxetine in the mouse-Posner task.

Shuting Li, Carlos May, Terence Y Pang, Leonid Churilov, Anthony J Hannan, Katherine A Johnson, Emma L Burrows

Abstract read
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In one paragraph

Article in Psychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Shuting LiMelbourne School of Psychological Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia. shutingli36@gmail.com.ORCID http://orcid.org/0000-0001-5863-7256
Carlos MayFlorey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.
Terence Y PangFlorey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.
Leonid ChurilovMelbourne Medical School, The University of Melbourne, Parkville, VIC, 3010, Australia.
Anthony J HannanFlorey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.
Katherine A JohnsonMelbourne School of Psychological Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.
Emma L BurrowsFlorey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia. emma.burrows@florey.edu.au.
The University of Melbourne · AUFlorey Institute of Neuroscience and Mental Health · AU

Funding

Australian Research Council FT100100835National Health and Medical Research Council-Australian Research Council 1111552
6 · The paper itself

Abstract

rationaleAtypical attention orienting has been associated with some autistic symptoms, but the neural mechanisms remain unclear. The human Posner task, a classic attention orienting paradigm, was recently adapted for use with mice, supporting the investigation of the neurobiological underpinnings of atypical attention orienting in preclinical mouse models.

objectiveThe current study tested mice expressing the autism-associated R451C gene mutation in neuroligin-3 (NL3) on the mouse-Posner (mPosner) task.

methodsNL3

resultsIn both tasks, mice were quicker and more accurate in the validly versus invalidly cued trials, consistent with results in the human Posner task. NL3

conclusionsNL3

Indexed as

Autistic DisorderAnimalsAtomoxetine HydrochlorideAttentionHumansMiceMutationNeuroliginsAtomoxetine HydrochlorideNeuroliginsAttention orientingAutism spectrum disorderMouse modelMouse-Posner taskNeuroligin-3 R451C mutationTouchscreen test

Identifiers

PMID38170320
OpenAlexW4390570595

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.