Evidence map›Paper›PMID 38170315›Full record

ArticleApplied microbiology and biotechnology2024

Construction of rBCG carrying the IL-2-BZLF1 fusion gene and its immunological function.

Meimei Yu, Tian Mi, Jiaqi Lu, Lixian Cui, Qingjie Xue, Huabao Xiong, Yinlong Li

Open access · goldAbstract read
In one paragraph

Article in Applied microbiology and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Bacterial live therapeutics for human diseases.Molecular systems biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Meimei Yu *School of Basic Medical, Jining Medical University, Jining, 272067, Shandong, China.
Tian Mi *School of Basic Medical, Jining Medical University, Jining, 272067, Shandong, China.
Jiaqi Lu *School of Basic Medical, Jining Medical University, Jining, 272067, Shandong, China.
Lixian CuiSchool of Basic Medical, Jining Medical University, Jining, 272067, Shandong, China.
Qingjie XueSchool of Basic Medical, Jining Medical University, Jining, 272067, Shandong, China. qjxue9797@mail.jnmc.edu.cn.ORCID http://orcid.org/0000-0001-5561-4091
Huabao XiongSchool of Basic Medical, Jining Medical University, Jining, 272067, Shandong, China. huabao.Xiong@mssm.edu.
Yinlong LiSchool of Public Health, Jining Medical University, Jining, 272067, China. 75294669@qq.com.
Jining Medical University · CNQingdao University · CN

Funding

Key Technology Research and Development Program of Shandong 2018GCF118137
6 · The paper itself

Abstract

In this research, a recombinant Bacillus Calmette Guerin (rBCG) vector vaccine carrying a human IL-2 and EBV BZLF1 fusion gene (IL-2-BZLF1-rBCG) was constructed. The IL-2-BZLF1-rBCG construct was successfully generated and stably expressed the IL-2 and BZLF1 proteins. IL-2-BZLF1-rBCG activated the immune system and promoted the secretion of IFN-γ and TNF-α by CD4

Indexed as

Mycobacterium bovisNeoplasmsBCG VaccineCD8-Positive T-LymphocytesHumansInterleukin-2Trans-ActivatorsBCG VaccineBZLF1 protein, Herpesvirus 4, HumanInterleukin-2Trans-ActivatorsBCGBZLF1Epstein-Barr virusIL-2Tumor

Identifiers

PMID38170315
PMCPMC13497776
OpenAlexW4390572065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.