ArticleThe journal of physical chemistry letters2024
New Insights into the Molecular Structure of Tear Film Lipids Revealed by Surface X-ray Scattering.
Article in The journal of physical chemistry letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Working toward Improved Chemical Covers for Water Conservation: A Laboratory-scale Assessment of Antievaporative Lipid Films.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Stability and Compressibility of Tear Film Lipid Layer: Impact of Benzalkonium Chloride Presence.bioRxiv : the preprint server for biology · 2026Article
- One Step Closer to a Molecular Level Understanding of the Tear Film Lipid Layer by Surface X-ray Scattering.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Decipher 'Em All: A Profiling Study on the Effects of Acyl Groups inLangmuir : the ACS journal of surfaces and colloids · 2024Article
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Authors and funding
12 authors.
Funding
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Abstract
The tear film lipid layer (TFLL) is a unique biological membrane that serves a pivotal role in the maintenance of ocular surface health. Reaching an overarching understanding of the functional principle of the TFLL has been hampered by a lack of insights into the structural and functional roles played by individual lipid classes. To bridge this knowledge gap, we herein focus on studying films formed by principal lipid classes by surface scattering methods. Through grazing incidence X-ray diffraction and X-ray reflectivity studies, we reveal quantitative data about the lattice distances, molecular tilt angles, and mono/multilayer thickness and density profiles for central TFLL lipid classes under close to simulated physiological conditions. In addition, we discuss the correlation of the results to those obtained previously with the natural lipid composition of meibum.
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