ArticleGeneral psychiatry2023
Social isolation, loneliness and subsequent risk of major adverse cardiovascular events among individuals with type 2 diabetes mellitus.
Article in General psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Loneliness, social isolation, and living alone: a comprehensive systematic review, meta-analysis, and meta-regression of mortality risks in older adults.Aging clinical and experimental research · 2025Pooled it
- The joint association of loneliness, social isolation, and satisfaction with major depressive disorder incidence in individuals with diabetes.Endocrine · 2026Article
- Evaluation of a Gamification-Based Intervention to Enhance Intergenerational Communication: Pre-Post Mixed Methods Evaluation.JMIR aging · 2026Article
- Exploring the association of poor social support and loneliness with cardiovascular history among lebanese residents: insights into myocardial infarction and stroke: a cross-sectional approach.BMC cardiovascular disorders · 2026Article
- The combined impact of social isolation and unhealthy risk score on mortality risk: a study from two prospective cohorts.BMC public health · 2026Article
- Social isolation and 59 common health conditions: insights from observational and genetics analyses.BMC medicine · 2026Article
- Loneliness and social isolation in transitions to adverse health conditions and mortality: an analysis of data from the UK Biobank study.Journal of epidemiology and community health · 2026Article
- Social Isolation and Incidence of Chest Pain and Mortality in Older Adults of the United States Population: A Cross-Sectional Study From NHANES 2001-2018.Health science reports · 2026Article
- Frailty, social disconnection, metabolomic signatures, and incident peripheral artery disease in type 2 diabetes: a prospective cohort study.Frontiers in nutrition · 2026Article
- Mediating Effect of Established Risk Factors on Association Between Social Determinants and Cardiovascular Disease Mortality.JACC. Advances · 2025Article
- Loneliness and Social Isolation in Individuals with Acute Myocardial Infarction and Takotsubo Syndrome: A Scoping Review.Healthcare (Basel, Switzerland) · 2025Review
- Psychosocial and behavioral risk patterns and risk of cardiovascular complications in people with type 2 diabetes.Diabetes research and clinical practice · 2025Article
- Observational and genetic evidence disagree on the association between loneliness and risk of multiple diseases.Nature human behaviour · 2024Article
- Exploring the association of social connections and food security among adults with uncontrolled type 2 diabetes: a population-based study.Journal of health, population, and nutrition · 2024Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Individuals with type 2 diabetes mellitus (T2DM) are more vulnerable to social disconnection compared with the general population; however, there are few relevant studies investigating this issue. Aims: To investigate whether social isolation or loneliness may be associated with subsequent risk of developing major adverse cardiovascular events, whether these associations vary according to fatal and non-fatal outcomes and how behavioural, psychological and physiological factors mediate these associations. Methods: This longitudinal analysis included data from 19 360 individuals with T2DM at baseline (2006-2010) from the UK Biobank. Social isolation and loneliness were measured using self-report questionnaires. The study outcomes included the first events of myocardial infarction (MI) or stroke (n=2273) and all-cause (n=2820) or cardiovascular disease-related mortality through linked hospital data or death registries. Results: Over a median follow-up of 12.4 years (interquartile range (IQR): 11.6-13.3 years), participants who were more socially isolated (most social isolation vs least social isolation) experienced increased risks for all-cause (hazard ratio (HR) : 1.33, 95% confidence interval (CI): 1.19 to 1.47) and cardiovascular disease (HR: 1.36, 95% CI: 1.17 to 1.59) mortality but not first MI or stroke. Loneliness (yes vs no) was associated with a greater risk for a composite of incident MI or stroke (HR: 1.37, 95% CI: 1.19 to 1.57) but not mortality. Social isolation was associated with fatal MI and stroke, whereas loneliness was associated with non-fatal MI and stroke. The significant associations of social isolation and loneliness with outcomes were mainly mediated by behavioural factors (mediating proportion: 17.8%-28.2% and 17.6%-17.8%, respectively). Conclusions: Among individuals with T2DM, social isolation and loneliness are associated with a greater risk of developing major adverse cardiovascular events, with differences in both risks stratified according to fatal and non-fatal events and underlying mediating factors.
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