SynthesisFrontiers in public health2023
Heart rate variability status at rest in adult depressed patients: a systematic review and meta-analysis.
Synthesis in Frontiers in public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association Between Physical Activity, Heart Rate Variability and Major Depressive Disorders: An Umbrella Review.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Depression and Risk of Sudden Cardiac Death and Arrhythmias: A Systematic Review and Meta-Analysis.Reviews in cardiovascular medicine · 2025Pooled it
- Resonance frequency versus fixed 0.1 Hz breathing in HRV biofeedback: a four-week randomized comparison.Scientific reports · 2026Trial
- Effects of heat-treatedFrontiers in nutrition · 2026Trial
- The heart knows best: baseline heart rate variability as guide to transcutaneous auricular vagus nerve stimulation in depression.Translational psychiatry · 2025Trial
- The Cumulative Effect of a 12-Week Online Mindfulness-Based Meditation Intervention Programme on Autonomic Nerve Functions by Pupillary Light Reflex: A Pilot Randomised Controlled Trial.Stress and health : journal of the International Society for the Investigation of Stress · 2025Trial
- Psychobiological Stress Regulation in Depressive Women Achieved Through Group Music Therapy: Results From the Randomised-Controlled Music Therapy for Depression Study.Stress and health : journal of the International Society for the Investigation of Stress · 2025Trial
- Artificial Intelligence in the Assessment of Heart Rate Variability as an Instrument to Understand the Connection Between Psychologic and Psychiatric Conditions and the Heart.Bioengineering (Basel, Switzerland) · 2026Review
- The Mental Health-Acute Coronary Syndrome Continuum: Bidirectional Pathophysiological Links and Clinical Implications.Medical sciences (Basel, Switzerland) · 2026Review
- Resting State Heart Rate Variability in Depression: An Introductory Narrative Review of Cross-Sectional and Longitudinal Evidence.Journal of personalized medicine · 2026Review
- Why The Polyvagal Theory Is Untenable: An international expert evaluation of the polyvagal theory and commentary upon Porges, S.W. (2025). Polyvagal theory: current status, clinical applications, and future directions. Clin. Neuropsychiatry, 22(3), 169-184.Clinical neuropsychiatry · 2026Article
- Contactless depression screening via facial video-derived heart rate variability.Translational psychiatry · 2026Article
- Tracking the longitudinal course of physiologic and mental health functioning among individuals in substance use disorder treatment.Frontiers in psychiatry · 2026Article
- Multimodal clinical, sleep, and autonomic correlates across the depressive spectrum: a cross-sectional study.Frontiers in psychology · 2026Article
- Plant-derived bioactives in depression-related and antidepressant-associated sexual dysfunction: a narrative review.Frontiers in nutrition · 2026Review
- Interpreting heart rate variability in clinical context: a framework for understanding a multidimensional autonomic biomarker.Frontiers in cardiovascular medicine · 2026Review
- A refined SMOTE-ENN optimization method based on machine learning for heart rate variability data classification.Frontiers in digital health · 2026Article
- Association Between Depressive Symptoms and Altered Heart Rate Variability in Obstructive Sleep Apnea.Journal of clinical medicine · 2025Article
- Association Between Trajectories of Depressive Symptoms and Cardiovascular Disease in Elderly Chinese Adults: Findings From the China Health and Retirement Longitudinal Study (CHARLS).Brain and behavior · 2025Article
- No relationship between inflammatory cytokines, heart rate variability, and morphology of the vagus nerves in patients with major depressive disorder.Brain, behavior, & immunity - health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purposes: A meta-analysis was conducted to examine the differences in heart rate variability (HRV) between depressed patients and healthy individuals, with the purpose of providing a theoretical basis for the diagnosis of depression and the prevention of cardiovascular diseases. Methods: To search China National Knowledge Infrastructure (CNKI), WanFang, VIP, PubMed, Web of Science, Science Direct, and Cochrane Library databases to collect case-control studies on HRV in depressed patients, the retrieval date is from the establishment of the database to December 2022. Effective Public Health Practice Project (EPHPP) scale was used to evaluate literature quality, and Stata14.0 software was used for meta-analysis. Results: This study comprised of 43 papers, 22 written in Chinese and 21 in English, that included 2,359 subjects in the depression group and 3,547 in the healthy control group. Meta-analysis results showed that compared with the healthy control group, patients with depression had lower SDNN [ Conclusion: This research revealed that HRV measures of depressed individuals were lower than those of the healthy population, except for LF/HF, suggesting that people with depression may be more at risk of cardiovascular diseases than the healthy population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.