Evidence map›Paper›PMID 38169709›Full record

ArticleHeliyon2024

Altered metabolism in right basal ganglia associated with asymptomatic neurocognitive impairment in HIV-infected individuals.

Yi Zhan, Dan-Chao Cai, Ying Liu, Fengxiang Song, Fei Shan, Pengrui Song, Guochao Chen, Yijun Zhang, He Wang, Yuxin Shi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yi ZhanDepartment of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Dan-Chao CaiDepartment of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Ying LiuInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Fengxiang SongDepartment of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Fei ShanDepartment of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Pengrui SongDepartment of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Guochao ChenDepartment of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yijun ZhangDepartment of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
He WangInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Yuxin ShiDepartment of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Shanghai Public Health Clinical Center · CNFudan University · CN

Funding

Altered auditory networks in HIV-induced central nervous system dysfunctionR01NS108809 · NINDS · DARTMOUTH COLLEGE · PI BUCKEY, JAY C · 2018 to 2022
$3.2M
NINDS NIH HHS R01 NS108809
6 · The paper itself

Abstract

Background: Only few studies have focused on the metabolite differences between asymptomatic neurocognitive impairment (ANI) and cognitively normal people living with HIV (PLWH). The current study aims to examine whether brain metabolisms in basal ganglia (BG) by magnetic resonance spectroscopy (MRS) were potential to discriminate ANI from cognitively normal PLWH. Methods: According to neuropsychological (NP) test, 80 PLWH (37.4 ± 10.2 years) were divided into ANI group (HIV-ANI, n = 31) and NP normal group (HIV-normal, n = 49). Brain metabolisms by MRS from right BG were compared between groups, including Results: Compared to HIV-normal group, tNAA/total was lower and tCr/total was higher in the HIV-ANI group ( Conclusion: The altered brain metabolites in the right BG were found in the ANI group compared to PLWH with normal cognition, and further associated with NP deficits. The current findings indicated that brain metabolites assessed by MRS has the potential to discriminate ANI from cognitively normal PLWH.

Indexed as

Asymptomatic neurocognitive impairmentHIV-Associated neurocognitive disorderHuman immunodeficiency virusNeuropsychological testSingle-voxel proton MR spectroscopy

Identifiers

PMID38169709
PMCPMC10758793
OpenAlexW4389396344

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.