Evidence map›Paper›PMID 38169668›Full record

ArticleMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention2023

Generating Realistic Brain MRIs via a Conditional Diffusion Probabilistic Model.

Wei Peng, Ehsan Adeli, Tomas Bosschieter, Sang Hyun Park, Qingyu Zhao, Kilian M Pohl

Abstract read
In one paragraph

Article in Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Integrating Anatomical Priors Into a Causal Diffusion Model.IEEE transactions on medical imaging · 2026
    Article
  3. Article
  4. Article
  5. Latent Causal Modeling for 3D Brain MRI Counterfactuals.Deep generative models : 5th MICCAI workshop, DGM4MICCAI 2025, held in conjunction with MICCAI 2025, Daejeon, South Korea, September 23, 2025, Proceedings. DGM4MICCAI (Workshop) (5th : 2025 : Taejon-si, Korea) · 2026
    Article
  6. Evaluation of 3D Counterfactual Brain MRI Generation.Deep generative models : 5th MICCAI workshop, DGM4MICCAI 2025, held in conjunction with MICCAI 2025, Daejeon, South Korea, September 23, 2025, Proceedings. DGM4MICCAI (Workshop) (5th : 2025 : Taejon-si, Korea) · 2026
    Article
  7. Article
  8. Review
  9. Latent Drifting in Diffusion Models for Counterfactual Medical Image Synthesis.Proceedings. IEEE Computer Society Conference on Computer Vision and Pattern Recognition · 2025
    Article
  10. S2S2: Semantic Stacking for Robust Semantic Segmentation in Medical Imaging.Proceedings of the ... AAAI Conference on Artificial Intelligence. AAAI Conference on Artificial Intelligence · 2025
    Article
  11. Review
  12. Disentangled latent energy-based style translation: An image-level structural MRI harmonization framework.Neural networks : the official journal of the International Neural Network Society · 2025
    Article
  13. Article
  14. Mitigating Data Scarcity in the Classification of Glioma Molecular Subtypes: The Power of Generative Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Evaluating the Quality of Brain MRI Generators.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2024
    Article
  19. Synthesizing 3D Multi-Contrast Brain Tumor MRIs Using Tumor Mask Conditioning.Proceedings of SPIE--the International Society for Optical Engineering · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wei PengStanford University, Stanford, CA 94305, USA.ORCID 0000-0002-2892-5764
Ehsan AdeliStanford University, Stanford, CA 94305, USA.ORCID 0000-0002-0579-7763
Tomas BosschieterStanford University, Stanford, CA 94305, USA.ORCID 0000-0001-9726-6400
Sang Hyun ParkDaegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.ORCID 0000-0001-7476-1046
Qingyu ZhaoStanford University, Stanford, CA 94305, USA.ORCID 0000-0002-6368-0889
Kilian M PohlStanford University, Stanford, CA 94305, USA.ORCID 0000-0001-5416-5159

Funding

TRACKING HIV INFECTION AND ALCOHOL ABUSE CNS COMORBIDITY WITH NEUROIMAGINGU01AA017347 · NIAAA · SRI INTERNATIONAL · PI PFEFFERBAUM, ADOLF, SULLIVAN, EDITH VIONI · 2007 to 2021
$16.0M
CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISMR01AA005965 · NIAAA · STANFORD UNIVERSITY · PI PFEFFERBAUM, ADOLF, ZAHR, NATALIE M · 1985 to 2025
$13.0M
NCANDA: Data Analysis Resource - Uploading Legacy Data to NDAU24AA021697 · NIAAA · STANFORD UNIVERSITY · PI Adolf Pfefferbaum, Kilian Maria Pohl · 2016 to 2026
$12.2M
CEREBELLAR STRUCTURE AND FUNCTION IN ALCOHOLISMR01AA010723 · NIAAA · STANFORD UNIVERSITY · PI SULLIVAN, EDITH VIONI, ZAHR, NATALIE M · 1996 to 2025
$8.3M
Machine learning to distinguish HAND from Alzheimer's disease in HIV over age 60R01MH113406 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POHL, KILIAN MARIA, VALCOUR, VICTOR · 2017 to 2021
$5.5M
Cerebellar Structure and Function in AlcoholismR37AA010723 · NIAAA · STANFORD UNIVERSITY · PI SULLIVAN, EDITH VIONI · 2010 to 2019
$5.4M
Tracking HIV Infection & Alcohol Abuse CNS Comorbidity with NeuroimagingR01AA017347 · NIAAA · SRI INTERNATIONAL · PI Adolf Pfefferbaum · 2022 to 2026
$5.2M
CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISMR37AA005965 · NIAAA · STANFORD UNIVERSITY · PI PFEFFERBAUM, ADOLF · 1996 to 2005
$4.4M
N-CANDA: DATA ANALYSIS COMPONENTU01AA021697 · NIAAA · SRI INTERNATIONAL · PI PFEFFERBAUM, ADOLF, POHL, KILIAN MARIA · 2012 to 2015
$3.6M
Interpretable Deep Forecasting of Hazardous Substance Use during High SchoolR01DA057567 · NIDA · STANFORD UNIVERSITY · PI Kilian Maria Pohl, Susan F. Tapert · 2022 to 2026
$2.3M
Longitudinal Analysis of Diffusion Tensor Imaging to Discover Adolescent Alcohol Use EffectR00AA028840 · NIAAA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Qingyu Zhao · 2024 to 2026
$747k
Longitudinal Analysis of Diffusion Tensor Imaging to Discover Adolescent Alcohol Use EffectK99AA028840 · NIAAA · STANFORD UNIVERSITY · PI ZHAO, QINGYU · 2021 to 2022
$284k
NIAAA NIH HHS K99 AA028840NIAAA NIH HHS R00 AA028840NIAAA NIH HHS R01 AA005965NIAAA NIH HHS R01 AA010723NIAAA NIH HHS R01 AA017347NIAAA NIH HHS R37 AA005965NIAAA NIH HHS R37 AA010723NIAAA NIH HHS U01 AA017347NIAAA NIH HHS U01 AA021697NIAAA NIH HHS U24 AA021697NIDA NIH HHS R01 DA057567NIMH NIH HHS R01 MH113406
6 · The paper itself

Abstract

As acquiring MRIs is expensive, neuroscience studies struggle to attain a sufficient number of them for properly training deep learning models. This challenge could be reduced by MRI synthesis, for which Generative Adversarial Networks (GANs) are popular. GANs, however, are commonly unstable and struggle with creating diverse and high-quality data. A more stable alternative is Diffusion Probabilistic Models (DPMs) with a fine-grained training strategy. To overcome their need for extensive computational resources, we propose a conditional DPM (cDPM) with a memory-efficient process that generates realistic-looking brain MRIs. To this end, we train a 2D cDPM to generate an MRI subvolume conditioned on another subset of slices from the same MRI. By generating slices using arbitrary combinations between condition and target slices, the model only requires limited computational resources to learn interdependencies between slices even if they are spatially far apart. After having learned these dependencies via an attention network, a new anatomy-consistent 3D brain MRI is generated by repeatedly applying the cDPM. Our experiments demonstrate that our method can generate high-quality 3D MRIs that share a similar distribution to real MRIs while still diversifying the training set. The code is available at https://github.com/xiaoiker/mask3DMRI_diffusion and also will be released as part of MONAI, at https://github.com/Project-MONAI/GenerativeModels.

Identifiers

PMID38169668
PMCPMC10758344

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.