Evidence map›Paper›PMID 38169630›Full record

ArticleFrontiers in public health2023

Cross-sectional analysis reveals COVID-19 pandemic community lockdown was linked to dysregulated cortisol and salivary alpha amylase in children.

Katherine M Lloyd, Laurel Gabard-Durnam, Kayleigh Beaudry, Michael De Lisio, Lauren B Raine, Ysabeau Bernard-Willis, Jennifer N H Watrous, Susan Whitfield-Gabrieli, Arthur F Kramer, Charles H Hillman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Katherine M LloydDepartment of Psychology, Northeastern University, Boston, MA, United States.
Laurel Gabard-DurnamDepartment of Psychology, Northeastern University, Boston, MA, United States.
Kayleigh BeaudryDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
Michael De LisioDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
Lauren B RaineDepartment of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, Boston, MA, United States.
Ysabeau Bernard-WillisDepartment of Psychology, Northeastern University, Boston, MA, United States.
Jennifer N H WatrousDepartment of Psychology, Oklahoma State University, Tulsa, OK, United States.
Susan Whitfield-GabrieliDepartment of Psychology, Northeastern University, Boston, MA, United States.
Arthur F KramerDepartment of Psychology, Northeastern University, Boston, MA, United States.
Charles H HillmanDepartment of Psychology, Northeastern University, Boston, MA, United States.
Northeastern University · USUniversity of Ottawa · CABrigham and Women's Hospital · USOklahoma State University at Tulsa · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic altered everyday life starting in March 2020. These alterations extended to the lives of children as their normal routines were disrupted by community lockdowns, online learning, limited in-person social contact, increased screen time, and reduced physical activity. Considerable research has investigated the physical health impact of COVID-19 infection, but far fewer studies have investigated the physiological impact of stressful pandemic-related changes to daily life, especially in children. The purpose of this study was to leverage an ongoing clinical trial to investigate physiological consequences associated with chronic stress of pandemic community lockdown on children. As a part of the clinical trial, children provided saliva samples. Saliva samples were analyzed for cortisol and salivary alpha amylase (sAA) content. This secondary cross-sectional analysis included 94 preadolescent children located within the Greater Boston, Massachusetts community. Children participated in the study either before, during, or following the pandemic community lockdown to form three groups for comparison. In response to chronic stress caused by the pandemic community lockdown, participants demonstrated dysregulation of fast-acting catecholamine response of the locus-coeruleus-norepinephrine system and slower-acting glucocorticoid response, resulting in an asymmetrical relationship of hypocortisolism (

Indexed as

COVID-19Salivary alpha-AmylasesChildCommunicable Disease ControlCross-Sectional StudiesHumansHydrocortisonePandemicsStress, PsychologicalHydrocortisoneSalivary alpha-AmylaseschildrencortisolCOVID- 19dysregulationsalivary alpha amylasestress

Identifiers

PMID38169630
PMCPMC10758420
OpenAlexW4389793332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.