ReviewCureus2023
Sex Differences in Infective Endocarditis: A Systematic Review.
Review in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Sex Disparities in Mortality and Clinical Characteristics in Patients with Infective Endocarditis: A Meta-Analysis of Reconstructed Time-to-Event Data.Cardiology · 2026Pooled it
- Sex Differences in Clinical Outcomes and Loss of Life Expectancy After Aortic Valve Surgery for Infective Endocarditis: A SWEDEHEART Study.Journal of the American Heart Association · 2026Observational
- Impact of sex on clinical management and mortality in community-onset Staphylococcus aureus bacteraemia: a retrospective study.BMC infectious diseases · 2026Article
- Sex Disparities in Infective Endocarditis Presentation, Management and Outcomes: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2026Review
- Indicators of In-Hospital Mortality in Infective Endocarditis: A Single-Center Retrospective Study.Cureus · 2026Article
- Gender-Based Analysis of Patients Undergoing Mitral Valve Surgery.Journal of clinical medicine · 2025Article
- Sex differences in a murine model of infective endocarditis.Basic research in cardiology · 2025Article
- Sex Differences in Clinical Outcomes and Surgical Interventions for Infective Endocarditis: A Nationwide Registry.Open forum infectious diseases · 2025Article
- Exploring sex differences in infective endocarditis - a prospective, observational study from Western Norway.BMC cardiovascular disorders · 2025Observational
- Sex-specific differences in infective endocarditis: A systematic review and meta-analysis of clinical profiles and management outcomes.International journal of cardiology. Heart & vasculature · 2025Review
- The global burden of pediatric infective endocarditis (5-14 years): epidemiological patterns from 1990 to 2021 and projected trajectories.Frontiers in cardiovascular medicine · 2025Article
- Impact of patient gender on surgical outcomes of infective endocarditis in adults: a systematic review and meta-analysis protocol.Journal of surgical protocols and research methodologies · 2025Article
- Longitudinal Outcomes Following Mitral Valve Repair for Infective Endocarditis.Microorganisms · 2024Article
- Similar Outcomes in Males and Females Undergoing Surgery for Infective Endocarditis.Journal of clinical medicine · 2024Article
- Men's more frequent predisposing factors in infectious endocarditis facilitate improvement of outcomes by shortening of diagnostic delay.Frontiers in cardiovascular medicine · 2024Article
- [Comparison of the epidemiological, clinical and diagnostic characteristics of infective endocarditis of native and prosthetic valves in a Peruvian reference center].Archivos peruanos de cardiologia y cirugia cardiovascularArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the advancement in medicine, there is still a lack of understanding of the sex disparities in disease onset, progression, treatment, and outcome. In some life-threatening acute conditions, despite most patients with these illnesses being males, females have a significantly higher chance of mortality. This can be due to the differences in disease progression or healthcare disparities in managing the illness between the sexes. Treatment of illnesses tends to be more conservative for women without an explanation, but this disparity is due to the healthcare provider. Infective endocarditis (IE) is an acute life-threatening condition where bacteria latch onto and seed damaged endocardium, with some preliminary information reporting differences between the sexes. This paper aims to evaluate the sex disparities in the incidence, age, comorbidities, etiology, risk factors, manifestations, treatment, and outcomes of IE. From 2003-2023, 21584 articles were found that focused on the sex differences in IE and, through PRISMA guidelines, were narrowed down to 34 publications. There are significant differences between the sexes in IE, such as a significantly higher incidence of IE in males, who also tend to be older and have their native aortic valves involved, compared to younger females who have their mitral valve involved. Comorbidities also vary between the sexes; females tend to have atrial fibrillation, chronic kidney disease, psychiatric disorders, and taking immunosuppressants compared to males who suffer from chronic liver disease, underlying valve disease, and peripheral artery disease, contributing to the ease of developing IE. While the most common microorganism leading to IE is
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.