Evidence map›Paper›PMID 38169592›Full record

ArticleInternational journal of medical sciences2024

N-cadherin Alleviates Apoptosis and Senescence of Nucleus Pulposus Cells via Suppressing ROS-dependent ERS in the Hyper-osmolarity Microenvironment.

Luetao Zou, Yiyang Wang, Yanzhu Hu, Liehua Liu, Lei Luo, Zhao Chen, Yunyun Zhuo, Pei Li, Qiang Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Luetao ZouDepartment of Orthopedics, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Yiyang WangDepartment of Orthopedics, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Yanzhu HuDepartment of Orthopedics, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Liehua LiuDepartment of Orthopedics, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Lei LuoDepartment of Orthopedics, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Zhao ChenDepartment of Orthopedics, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Yunyun ZhuoDepartment of Orthopedics, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Pei LiDepartment of Orthopedics, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Qiang ZhouDepartment of Orthopedics, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The in-situ osmolarity is an important physicochemical factor that regulates cell fate of nucleus pulposus cells (NPCs). Our previous studies demonstrated that reduced N-cadherin (NCDH) expression in nucleus pulposus cells is associated with cellular damage under hyper-osmolarity microenvironment. This study was aimed at exploring the impacts of NCDH on senescence and apoptosis of NPCs, as well as the potential molecular mechanism. By comparing NPCs from patients with lumbar fractures and lumbar disc herniation, we identified a correlation between decreased NCDH expression and increased endoplasmic reticulum stress (ERS), resulting in undesirable cell fate (senescence and apoptosis). After blocking Reactive oxygen species (ROS) or ERS, it was indicated that hyper-osmolarity microenvironment induced ERS was ROS-dependent. Further results demonstrated the correlation in rat NPCs. Upregulation of NCDH expression reduced ROS-dependent ERS, thus limiting undesirable cell fates

Indexed as

Intervertebral Disc DegenerationNucleus PulposusAnimalsAntigens, CDApoptosisCadherinsCellular SenescenceEndoplasmic Reticulum StressHumansNerve Tissue ProteinsOsmolar ConcentrationRatsReactive Oxygen SpeciesAntigens, CDCadherinsCDH2 protein, humanN-cadherin, ratNerve Tissue ProteinsReactive Oxygen Speciesendoplasmic reticulum stresshyper-osmolarity microenvironmentintervertebral disc degenerationN-cadherinnucleus pulposus cells

Identifiers

PMID38169592
PMCPMC10758147
OpenAlexW4389340088

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.