ArticleNature communications2024
Quantum plasmonics pushes chiral sensing limit to single molecules: a paradigm for chiral biodetections.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed.
- Ultrasensitive chiral detection by nonlinear chiroptics in spiral plasmonic metastructures surpasses linear limits.Science advances · 2026Article
- Deep-ultraviolet chiral interband plasmonics in silicon nanohelices.Microsystems & nanoengineering · 2026Article
- Fused deep learning enables 6D single-molecule localization in polarization-resolved microscopy.Methods and applications in fluorescence · 2026Article
- Dual-parameter chiral detection at the single-particle level enabled by surface cosine waves.Science advances · 2026Article
- Extreme Polaritonic Interactions in a Room-Temperature Designable Sub-Nanocavity Quantum Electrodynamic Platform.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Twist-encoded magnetic plasmon interferometry for label-free, orientation-resolved single-molecule imaging.Science advances · 2026Article
- Chiral Light-Matter Interaction for Controlling Nanoplasmonic Fields.Nanophotonics (Berlin, Germany) · 2026Article
- High-Q multimodal guided-surface lattice resonances in index-discontinuous environments.Nature communications · 2026Article
- Chiral nonlinear polaritonics with van der Waals metasurfaces.Science advances · 2026Article
- Colorimetric detection of amino acids enabled by functional nanomaterials: mechanisms, performance evaluation, and translational perspectives.Mikrochimica acta · 2026Review
- Engineering Chiroptical Interactions through Integrating Plasmonic Arrays with Cholesteric Nanocellulose.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Compressing Few-Cycle Optical Near Fields in the Tip-Sample Junction of a Scanning Probe Microscope.Nano letters · 2026Article
- Quantum Hydrodynamic Theory for Sub-Nanometer Gaps: Atomic Protrusions Govern Near-Field Enhancement and Tunneling Signatures.Materials (Basel, Switzerland) · 2026Article
- Multidimensional helical dichroism from a chiral molecular nanoassembly.Nature communications · 2026Article
- Near-unity fueling light into a single plasmonic nanocavity.Nanophotonics (Berlin, Germany) · 2025Article
- Charge transfer at the plasmon-molecule interfaces controls the collective chiroptical responses.Nature communications · 2025Article
- Dark-Field Scattering Imaging and Spectroscopy.ACS applied materials & interfaces · 2025Review
- Chiral Imprinting on Inorganic Nanoparticles for Enantioselective Surface Recognition.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Circular Polarimetric Imaging with a Metamaterial Integrated Long-Wavelength Infrared Focal Plane Array.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Single molecule orientation and localization microscopy.Nature photonics · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Chiral sensing of single molecules is vital for the understanding of chirality and their applications in biomedicine. However, current technologies face severe limitations in achieving single-molecule sensitivity. Here we overcome these limitations by designing a tunable chiral supramolecular plasmonic system made of helical oligoamide sequences (OS) and nanoparticle-on-mirror (NPoM) resonator, which works across the classical and quantum regimes. Our design enhances the chiral sensitivity in the quantum tunnelling regime despite of the reduced local E-field, which is due to the strong Coulomb interactions between the chiral OSs and the achiral NPoMs and the additional enhancement from tunnelling electrons. A minimum of four molecules per single-Au particle can be detected, which allows for the detection of an enantiomeric excess within a monolayer, manifesting great potential for the chiral sensing of single molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.