Evidence map›Paper›PMID 38169457›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

Serotonin Strengthens a Developing Glutamatergic Synapse through a PI3K-Dependent Mechanism.

Uwemedimo G Udoh, John R Bruno, Paige O Osborn, Kara G Pratt

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Uwemedimo G UdohDepartment of Zoology and Physiology, University of Wyoming, Laramie 82071, Wyoming.ORCID 0000-0001-6616-3409
John R BrunoDepartment of Zoology and Physiology, University of Wyoming, Laramie 82071, Wyoming.
Paige O OsbornDepartment of Zoology and Physiology, University of Wyoming, Laramie 82071, Wyoming.
Kara G PrattDepartment of Zoology and Physiology, University of Wyoming, Laramie 82071, Wyoming kpratt4@uwyo.edu.ORCID 0000-0002-6743-4757
University of Wyoming · US

Funding

Wyoming INBRE Phase 4- Equipment Supplement for x-ray diffractometer for Center for Advanced Scientific InstrumentationP20GM103432 · NIGMS · UNIVERSITY OF WYOMING · PI Nicolas A. Blouin · 2012 to 2026
$56.8M
Zebrafish Models of CNS Injury and Locomotor RecoveryP20GM121310 · NIGMS · UNIVERSITY OF WYOMING · PI Qian-Quan Sun · 2017 to 2026
$27.2M
NIGMS NIH HHS P20 GM103432NIGMS NIH HHS P20 GM121310
6 · The paper itself

Abstract

It is well established that, during neural circuit development, glutamatergic synapses become strengthened via NMDA receptor (NMDAR)-dependent upregulation of AMPA receptor (AMPAR)-mediated currents. In addition, however, it is known that the neuromodulator serotonin is present throughout most regions of the vertebrate brain while synapses are forming and being shaped by activity-dependent processes. This suggests that serotonin may modulate or contribute to these processes. Here, we investigate the role of serotonin in the developing retinotectal projection of the

Indexed as

Phosphatidylinositol 3-KinasesSerotoninalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidNeuronsReceptors, AMPAReceptors, N-Methyl-D-AspartateSynapsesSynaptic Transmissionalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidPhosphatidylinositol 3-KinasesReceptors, AMPAReceptors, N-Methyl-D-AspartateSerotonindevelopmentglutamateretinotectalserotoninsynapsesXenopus

Identifiers

PMID38169457
PMCPMC10860612
OpenAlexW4390595524

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.