Evidence map›Paper›PMID 38169296›Full record

ArticleJournal of bacteriology2024

The histidine kinase NahK regulates pyocyanin production through the PQS system.

Alicia G Mendoza, Danielle Guercio, Marina K Smiley, Gaurav K Sharma, Jason M Withorn, Natalie V Hudson-Smith, Chika Ndukwe, Lars E P Dietrich, Elizabeth M Boon

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Functional organization and regulatory logic of theApplied and environmental microbiology · 2026
    Review
  3. Review
  4. Article
  5. Frontiers in microbiology · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Alicia G MendozaDepartment of Microbiology and Immunology, Stony Brook University , Stony Brook, New York, USA.ORCID 0000-0001-5010-2951
Danielle GuercioDepartment of Molecular and Cellular Biology, Stony Brook University , Stony Brook, New York, USA.
Marina K SmileyDepartment of Biological Sciences, Columbia University , New York, New York, USA.
Gaurav K SharmaDepartment of Chemistry, Stony Brook University , Stony Brook, New York, USA.
Jason M WithornDepartment of Chemistry, Stony Brook University , Stony Brook, New York, USA.
Natalie V Hudson-SmithDepartment of Chemistry, Stony Brook University , Stony Brook, New York, USA.
Chika NdukweDepartment of Chemistry, Stony Brook University , Stony Brook, New York, USA.
Lars E P DietrichDepartment of Biological Sciences, Columbia University , New York, New York, USA.ORCID 0000-0003-2049-1137
Elizabeth M BoonDepartment of Chemistry, Stony Brook University , Stony Brook, New York, USA.ORCID 0000-0003-1891-839X
Stony Brook University · USColumbia University · US

Funding

Integration of redox-balancing mechanisms in Pseudomonas aeruginosa biofilmsR01AI103369 · NIAID · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DIETRICH, LARS · 2013 to 2022
$4.1M
MOLECULAR AND CELL BIOLOGY OF INFECTIOUS DISEASEST32AI007539 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI KONOPKA, JAMES B · 1998 to 2023
$3.6M
The role of NosP in Pseudomonas aeruginosa biofilm developmentR01GM118894 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI ELIZABETH M BOON · 2017 to 2026
$3.0M
Chemical Biology Training InterfaceT32GM136572 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI ELIZABETH M BOON, Jessica Chuang Seeliger · 2020 to 2026
$2.9M
NIAID NIH HHS R01 AI103369NIAID NIH HHS T32 AI007539NIGMS NIH HHS R01 GM118894NIGMS NIH HHS T32 GM136572
6 · The paper itself

Abstract

Many bacterial histidine kinases work in two-component systems that combine into larger multi-kinase networks. NahK is one of the kinases in the GacS Multi-Kinase Network (MKN), which is the MKN that controls biofilm regulation in the opportunistic pathogen

Indexed as

BiofilmsPyocyanineAnti-Bacterial AgentsBacteriaBacterial ProteinsHistidine KinasePseudomonas aeruginosaQuorum SensingVirulence FactorsAnti-Bacterial AgentsBacterial ProteinsHistidine KinasePyocyanineVirulence FactorsNahKnitric oxideNosPPQSpyocyaninquorum sensingsignalingvirulence

Identifiers

PMID38169296
PMCPMC10809955
OpenAlexW4390536432

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.