SynthesisCancer medicine2024
Effects of socioeconomic status on enrollment in clinical trials for cancer: A systematic review.
Synthesis in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Overcoming health misinformation in marginalized groups: a systematic review.International journal for equity in health · 2025Pooled it
- Lack of diversity in antifibrotic trials for pulmonary fibrosis: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Effects of socioeconomic status on enrollment in clinical trials for cancer: A systematic review.Cancer medicine · 2024Pooled it
- Impact of Smoking on Treatment Outcomes in Patients With Human Papillomavirus-Related Oropharyngeal Cancer.Head & neck · 2026Article
- On the Unfairness of the 'Fair-share Principle' for Health Research.Public health ethics · 2026Article
- Inequities in enrollment across clinical trial phases and the need for a Spanish perspective.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Barriers to Successful Research Compensation in a Multicenter Pediatric Acute Care Study.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2026Article
- The Clinical Trial Referral Ambassadors program to promote clinical trial referrals within rural community hospitals: A formative program evaluation study.Contemporary clinical trials · 2026Article
- Implementing a national clinical trial navigator program: a qualitative CFIR analysis of barriers and facilitators from the perspective of people with lived cancer experience.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Strategies for optimizing clinical trial recruitment: perspectives among patients with breast cancer.Cancer causes & control : CCC · 2026Article
- Investigating CAR-T Treatment Access for Multiple Myeloma Patients Using Real-World Evidence.Cancers · 2026Article
- Increasing Diversity in Head and Neck Cancer Clinical Trials.Current treatment options in oncology · 2026Review
- Factors associated with enrollment, adherence, and retention in a remotely delivered tobacco cessation randomized controlled trial.Tobacco prevention & cessation · 2026Article
- Socioeconomic disparities in patient-reported outcomes, health literacy, and access to care among patients with primary brain tumors: findings from the All of Us Research Program.Journal of neuro-oncology · 2025Article
- Real-world use of adjuvant nivolumab among patients with esophageal and gastroesophageal junction cancer at a large integrated health system.JTCVS open · 2025Article
- Examining the Association Between Equity-Related Factors and EQ-5D-3L Health Utilities of Patients with Cancer.Current oncology (Toronto, Ont.) · 2025Article
- Potential Barriers to Participating in Cancer Moonshot Biobank for Low-Income Patients with Cancer of Rural Maine.Biopreservation and biobanking · 2025Article
- Financial difficulty among patients with cancer participating in clinical trials and its association with patient survival and quality of life.Journal of the National Cancer Institute · 2025Article
- Diversity and inclusivity in oncology: A narrative review and orientation for institutional measures in Germany.Translational oncology · 2025Review
- Real-world effectiveness of palbociclib plus an aromatase inhibitor in HR+/HER2- MBC patients living in disadvantaged neighborhoods.NPJ breast cancer · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo achieve equitable access to cancer clinical trials (CCTs), patients must overcome structural, clinical, and attitudinal barriers to trial enrollment. The goal of this systematic review was to study the relationship between socioeconomic status (SES), assessed either by direct or proxy measures, and CCT enrollment.
methodsThe review team and medical librarian developed search strategies for each database to identify studies for this systematic review, which was conducted according to PRISMA guidelines. Inclusion criteria were as follows: studies published in relevant scientific journals between January 2000 and July 2022, primary sources, English literature, and studies conducted in the US. Sixteen studies fulfilled the inclusion criteria and were reviewed. The risk of bias assessment was conducted independently by two reviewers using the Newcastle Ottawa scale.
resultsThe initial search yielded 4070 citations, and 16 studies were included in our review. Four of the studies included used patient reported annual income as a measure of SES, while the remaining 12 studies used patient zip code as a proxy measurement of SES. Consistent with our hypothesis, 13 studies showed a positive association between high SES (patient-reported or proxy measurement) and CCT enrollment. Two studies showed a negative association, and one study showed no relationship.
conclusionsThe existing literature suggests that low SES is associated with lower participation in CCT. The small number of studies identified on this topic highlights the need for additional research on SES and other barriers to CCT participation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.