Evidence map›Paper›PMID 38168713›Full record

ArticleEuropean journal of applied physiology2024

Blood flow restriction augments the cross-education effect of isometric handgrip training.

Vickie Wong, Robert W Spitz, Jun Seob Song, Yujiro Yamada, Ryo Kataoka, William B Hammert, Anna Kang, Aldo Seffrin, Zachary W Bell, Jeremy P Loenneke

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in European journal of applied physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07309068 (Acute Effects of Blood Flow Restriction Training on Balance and Proprioception), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07309068 nacompletednot on this mapstarted 2025, after this paper: background citation

Acute Effects of Blood Flow Restriction Training on Balance and Proprioception: A Randomized Controlled Blinded StudyAcute BFR Training Effects on Balance and Proprioception

TypeinterventionalSponsorBiruni UniversityRan2025 to 2026Enrolled74ConditionsBlood Flow RestrictionArmsBFR, sham BFR, Proprioceptive Exercise Training
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Cross-Education of Muscular Endurance: A Scoping Review.Sports medicine (Auckland, N.Z.) · 2024
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vickie WongDepartment of Sport and Health, Solent University, Southampton, Hampshire, SO14 0YN, UK.
Robert W SpitzDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Jun Seob SongDepartment of Health, Exercise Science, and Recreation Management. Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, P.O. Box 1848, University, MS, USA.
Yujiro YamadaDepartment of Health, Exercise Science, and Recreation Management. Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, P.O. Box 1848, University, MS, USA.
Ryo KataokaDepartment of Health, Exercise Science, and Recreation Management. Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, P.O. Box 1848, University, MS, USA.
William B HammertDepartment of Health, Exercise Science, and Recreation Management. Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, P.O. Box 1848, University, MS, USA.
Anna KangDepartment of Health, Exercise Science, and Recreation Management. Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, P.O. Box 1848, University, MS, USA.
Aldo SeffrinDepartment of Health, Exercise Science, and Recreation Management. Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, P.O. Box 1848, University, MS, USA.
Zachary W BellDepartment of Kinesiology and Physical Education, McGill University, Montreal, QC, Canada.
Jeremy P LoennekeDepartment of Health, Exercise Science, and Recreation Management. Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, P.O. Box 1848, University, MS, USA. jploenne@olemiss.edu.ORCID http://orcid.org/0000-0001-5409-9075

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe application of blood flow restriction (BFR) to low-intensity exercise may be able to increase strength not only in the trained limb but also in the homologous untrained limb. Whether this effect is repeatable and how that change compares to that observed with higher intensity exercise is unknown. PURPOSE: Examine whether low-intensity training with BFR enhances the cross-education of strength compared to exercise without BFR and maximal efforts.

methodsA total of 179 participants completed the 6-week study, with 135 individuals performing isometric handgrip training over 18 sessions. Participants were randomly assigned to one of four groups: 1) low-intensity (4 × 2 min of 30% MVC; LI, n = 47), 2) low-intensity with blood flow restriction (LI + 50% arterial occlusion pressure; LI-BFR, n = 41), 3) maximal effort (4 × 5 s of 100% MVC; MAX, n = 47), and 4) non-exercise control (CON, n = 44).

resultsLI-BFR was the only group that observed a cross-education in strength (CON: 0.64 SD 2.9 kg, LI: 0.95 SD 3.6 kg, BFR-LI: 2.7 SD 3.3 kg, MAX: 0.80 SD 3.1 kg). In the trained hand, MAX observed the greatest change in strength (4.8 SD 3.3 kg) followed by LI-BFR (2.8 SD 4.0 kg). LI was not different from CON. Muscle thickness did not change in the untrained arm, but ulna muscle thickness was increased within the trained arm of the LI-BFR group (0.06 SD 0.11 cm).

conclusionIncorporating BFR into low-intensity isometric training led to a cross-education effect on strength that was greater than all other groups (including high-intensity training).

Indexed as

Hand StrengthIsometric ContractionMuscle, SkeletalAdultExerciseFemaleHumansMaleRegional Blood FlowResistance TrainingYoung AdultBFRCross-over effectStrengthUnilateral trainingUntrained limbUpper body

Identifiers

PMID38168713

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.