Evidence map›Paper›PMID 38168683›Full record

ArticleMicrobiology spectrum2024

Polymyxin B and ethylenediaminetetraacetic acid act synergistically against

Samuel J M Hale, Alan J Cameron, Christian A Lux, Kristi Biswas, Raymond Kim, Mark O'Carroll, Paul W R Harris, Richard G Douglas, Brett Wagner Mackenzie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. ACS omega · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samuel J M HaleDepartment of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Grafton, Auckland, New Zealand.ORCID 0000-0002-5860-2448
Alan J CameronSchool of Chemical Sciences and School of Biological Sciences, The University of Auckland, Auckland, New Zealand.
Christian A LuxDepartment of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Grafton, Auckland, New Zealand.
Kristi BiswasDepartment of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Grafton, Auckland, New Zealand.
Raymond KimDepartment of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Grafton, Auckland, New Zealand.
Mark O'CarrollRespiratory Services, Auckland City Hospital, Te Toka Tumai, Te Whatu Ora, Auckland, New Zealand.
Paul W R HarrisSchool of Chemical Sciences and School of Biological Sciences, The University of Auckland, Auckland, New Zealand.
Richard G DouglasDepartment of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Grafton, Auckland, New Zealand.ORCID 0000-0002-2900-0384
Brett Wagner MackenzieDepartment of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Grafton, Auckland, New Zealand.ORCID 0000-0002-5318-1808

Funding

Auckland Medical Research Foundation (AMRF) 1120008Garnett Passe and Rodney Williams Memorial Foundation (GPRWMF) 2020_ASSF_KIMGarnett Passe and Rodney Williams Memorial Foundation (GPRWMF) 2021_ASSRS_HALEGarnett Passe and Rodney Williams Memorial Foundation (GPRWMF) 2022_MCF_BISWASMaurice Wilkins Centre for Molecular Biodiscovery (Maurice Wilkins Centre) MWC4525
6 · The paper itself

Abstract

Polymyxin B and ethylenediaminetetraacetic acid are antimicrobials possessing antibiofilm activity. They act by displacement and chelation, respectively, of divalent cations in bacterial membranes and may therefore act synergistically when applied in combination. If so, this combination of agents may be useful for the treatment of diseases like cystic fibrosis (CF), in which biofilms are present on the respiratory epithelium. We used checkerboard assays to investigate the synergy between these agents using reference strains

Indexed as

Anti-Infective AgentsCystic FibrosisPseudomonas InfectionsStaphylococcal InfectionsAnti-Bacterial AgentsBiofilmsEdetic AcidHumansMicrobial Sensitivity TestsPolymyxin BPseudomonas aeruginosaStaphylococcus aureusAnti-Bacterial AgentsAnti-Infective AgentsEdetic AcidPolymyxin Bbiofilmscystic fibrosisEDTApolymyxinsPseudomonas aeruginosaStaphylococcus aureussynergism

Identifiers

PMID38168683
PMCPMC10845947

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.