ArticlebioRxiv : the preprint server for biology2023
Rescue of Impaired Blood-Brain Barrier in Tuberous Sclerosis Complex Patient Derived Neurovascular Unit.
Jacquelyn A Brown, Shannon L Faley, Monika Judge, Patricia Ward, Rebecca A Ihrie, Robert Carson, Laura Armstrong, Mustafa Sahin, John P Wikswo, Kevin C Ess and 1 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
11 authors.
Jacquelyn A BrownDept. of Physics and Astronomy, Vanderbilt University.
Shannon L FaleyDept. of Physics and Astronomy, Vanderbilt University.
Monika JudgeDept. of Physics and Astronomy, Vanderbilt University.
Patricia WardDept. of Physics and Astronomy, Vanderbilt University.
Robert CarsonDept. of Pediatrics, Vanderbilt University Medical Center.
Laura ArmstrongDept. of Pediatrics, Vanderbilt University Medical Center.
Mustafa SahinRosamund Stone Translational Neuroscience Center, Dept. of Neurology, Boston Children's Hospital, Harvard Medical School.ORCID 0000-0001-7044-2953 John P WikswoDept. of Physics and Astronomy, Vanderbilt University.
Kevin C EssNeurological Surgery, Vanderbilt University Medical Center.
M Diana NeelyDept. of Pediatrics, Vanderbilt University Medical Center.
Funding
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MToward better characterization and clinical trial readiness for targeting neuropsychiatric manifestations in PTEN pathogenic variantsU54NS092090 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI Joseph D. Buxbaum · 2014 to 2026
$20.1MDrug development for tuberous sclerosis complex and other pediatric epileptogenic diseases using neurovascular and cardiac microphysiological modelsUH3TR002097 · NCATS · VANDERBILT UNIVERSITY · PI ESS, KEVIN C, NEELY, MAJA DIANA · 2019 to 2021
$4.6MIdentifying mTOR Dependent Periods During Brain DevelopmentR01NS118580 · NINDS · VANDERBILT UNIVERSITY · PI ESS, KEVIN C, IHRIE, REBECCA A · 2020 to 2024
$2.1MNCATS NIH HHS UH3 TR002097NCATS NIH HHS UL1 TR002243NINDS NIH HHS R01 NS118580NINDS NIH HHS U54 NS092090
6 · The paper itselfAbstract
Tuberous sclerosis complex (TSC) is a multi-system genetic disease that causes benign tumors in the brain and other vital organs. The most debilitating symptoms result from involvement of the central nervous system and lead to a multitude of severe symptoms including seizures, intellectual disability, autism, and behavioral problems. TSC is caused by heterozygous mutations of either the
Indexed as
astrocytesBBBhuman stem cellsmicrofluidicsmTORrapamycintissue chips
Identifiers
PMID38168450
PMCPMC10760190
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