Evidence map›Paper›PMID 38168448›Full record

ArticlebioRxiv : the preprint server for biology2025

Stable Cortical Body Maps Before and After Arm Amputation.

Hunter R Schone, Roni O Maimon Mor, Mathew Kollamkulam, Malgorzata A Szymanska, Craig Gerrand, Alexander Woollard, Norbert V Kang, Chris I Baker, Tamar R Makin

Registry-linked trialAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07666204 (Using Sensorimotor Reorganization Following Upper Limb Amputation to Improve Prosthetic Control), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07666204 narecruitingnot on this mapstarted 2026, after this paper: background citation

Using Sensorimotor Reorganization Following Upper Limb Amputation to Improve Prosthetic Control

TypeinterventionalSponsorUnion de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord EstRan2026 to 2030Enrolled50ConditionsAmputation of Upper Limb, Agenesis of Upper LimbArmsCaracterisation, Mapping, Phantom sensations, Classification, Prosthetic control
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Hunter R SchoneInstitute of Cognitive Neuroscience, University College London, London, UK.ORCID 0000-0001-8496-2319
Roni O Maimon MorInstitute of Cognitive Neuroscience, University College London, London, UK.ORCID 0000-0001-5262-9976
Mathew KollamkulamInstitute of Cognitive Neuroscience, University College London, London, UK.
Malgorzata A SzymanskaMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Craig GerrandDepartment of Orthopaedic Oncology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, UK.
Alexander WoollardPlastic Surgery Department, Royal Free Hospital NHS Trust, London, UK.
Norbert V KangPlastic Surgery Department, Royal Free Hospital NHS Trust, London, UK.
Chris I BakerLaboratory of Brain & Cognition, National Institutes of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0001-6861-8964
Tamar R MakinInstitute of Cognitive Neuroscience, University College London, London, UK.ORCID 0000-0002-5816-8979

Funding

Learning and plasticity in the human brainZIAMH002893 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI BAKER, CHRIS · 2009 to 2025
$6.8M
Using Neuroprosthetics to Promote Plasticity in Cortical Motor CircuitsF32MH139145 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Hunter Schone · 2024 to 2026
$161k
Intramural NIH HHS ZIA MH002893NIMH NIH HHS F32 MH139145Wellcome Trust
6 · The paper itself

Abstract

The adult brain's capacity for cortical reorganization remains debated. Using longitudinal neuroimaging in three adults, followed up to five years before and after arm amputation, we compared cortical activity elicited by movement of the hand (pre-amputation) versus phantom hand (post-amputation) and lips (pre/post-amputation). We observed stable representations of both hand and lips. By directly quantifying activity changes across amputation, we overturn decades of animal and human research, demonstrating amputation does not trigger large-scale cortical reorganization.

Identifiers

PMID38168448
PMCPMC10760201

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.