Evidence map›Paper›PMID 38168446›Full record

ArticlebioRxiv : the preprint server for biology2023

Differential developmental blueprints of organ-intrinsic nervous systems.

I-Uen Hsu, Yingxin Lin, Yunshan Guo, Qian J Xu, Yuancheng Shao, Ruiqi L Wang, Dominic Yin, Jia Zhao, Lawrence H Young, Hongyu Zhao and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

I-Uen Hsu
Yingxin Lin
Yunshan Guo
Qian J Xu
Yuancheng Shao
Ruiqi L Wang
Dominic Yin
Jia Zhao
Lawrence H Young
Hongyu Zhao
Le ZhangORCID 0000-0002-4860-831X
Rui B Chang
Yale University · US

Funding

Understanding the molecular and functional architecture of diverse body-brain pathwaysR01AT012041 · NCCIH · YALE UNIVERSITY · PI CHANG, RUI · 2022 to 2025
$3.0M
Understand the little brain on the heart: a molecular and functional dissection of the intrinsic cardiac nervous systemDP2HL151354 · NHLBI · YALE UNIVERSITY · PI CHANG, RUI · 2019 to 2019
$2.5M
A molecular and functional dissection of the vagal heart-to-brain physiological circuitsR01HL150449 · NHLBI · YALE UNIVERSITY · PI CHANG, RUI · 2020 to 2023
$1.7M
NCCIH NIH HHS R01 AT012041NHLBI NIH HHS DP2 HL151354NHLBI NIH HHS R01 HL150449
6 · The paper itself

Abstract

The organ-intrinsic nervous system is a major interface between visceral organs and the brain, mediating important sensory and regulatory functions in the body-brain axis and serving as critical local processors for organ homeostasis. Molecularly, anatomically, and functionally, organ-intrinsic neurons are highly specialized for their host organs. However, the underlying mechanism that drives this specialization is largely unknown. Here, we describe the differential strategies utilized to achieve organ-specific organization between the enteric nervous system (ENS)

Identifiers

PMID38168446
PMCPMC10759999
OpenAlexW4389669884

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.