Evidence map›Paper›PMID 38168441›Full record

ArticlebioRxiv : the preprint server for biology2023

An Integrated Optogenetic and Bioelectronic Platform for Regulating Cardiomyocyte Function.

Olurotimi A Bolonduro, Zijing Chen, Yan-Ru Lai, Megan Cote, Akshita A Rao, Haitao Liu, Emmanuel S Tzanakakis, Brian P Timko

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Olurotimi A BolonduroDepartment of Biomedical Engineering, Tufts University.ORCID 0000-0002-3210-0650
Zijing ChenDepartment of Chemical and Biological Engineering, Tufts University.
Yan-Ru LaiDepartment of Biomedical Engineering, Tufts University.
Megan CoteDepartment of Biomedical Engineering, Tufts University.
Akshita A RaoDepartment of Biomedical Engineering, Tufts University.ORCID 0000-0001-7457-8188
Haitao LiuDepartment of Biomedical Engineering, Tufts University.ORCID 0000-0003-1824-0304
Emmanuel S TzanakakisDepartment of Chemical and Biological Engineering, Tufts University.ORCID 0000-0002-6677-352X
Brian P TimkoDepartment of Biomedical Engineering, Tufts University.ORCID 0000-0002-7958-8980

Funding

Translational Bioreactors - Engineering Complex TissuesP41EB002520 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2004 to 2018
$16.7M
Bioelectronics-embedded injectable hydrogel for neural regenerationR21EB034527 · NIBIB · UNIVERSITY OF NEW HAMPSHIRE · PI JEONG, KYUNG JAE, TIMKO, BRIAN PAUL · 2023 to 2023
$427k
NIBIB NIH HHS P41 EB002520NIBIB NIH HHS R21 EB034527
6 · The paper itself

Abstract

We report an integrated optogenetic and bioelectronic platform for stable and long-term modulation and monitoring of cardiomyocyte function in vitro. Optogenetic inputs were achieved through expression of a photoactivatable adenylyl cyclase (bPAC), that when activated by blue light caused a dose-dependent and time-limited increase in autonomous cardiomyocyte beat rate. Bioelectronic readouts were achieved through an integrated planar multi-electrode array (MEA) that provided real-time readouts of electrophysiological activity from 32 spatially-distinct locations. Irradiation at 27 μW/mm

Identifiers

PMID38168441
PMCPMC10760153

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.