ArticlemedRxiv : the preprint server for health sciences2023
Blood pressure variability, central autonomic network dysfunction and cerebral small vessel disease in APOE4 carriers.
Trevor Lohman, Isabel Sible, Arunima Kapoor, Allison C Engstrom, John Paul Alitin, Aimee Gaubert, Kathleen E Rodgers, David Bradford, Mara Mather, S Duke Han and 2 more
Open access · greenAbstract readPreprint
In one paragraphArticle in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 6 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
12 authors at 3 institutions in 1 country.
Trevor LohmanUniversity of Southern California Leonard Davis School of Gerontology, Los Angeles, CA, USA.ORCID 0000-0002-9634-702X Arunima KapoorDepartment of Psychological Science, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0003-4622-8951 Allison C EngstromDepartment of Psychological Science, University of California, Irvine, Irvine, CA, USA.
John Paul AlitinUniversity of Southern California Leonard Davis School of Gerontology, Los Angeles, CA, USA.
Aimee GaubertUniversity of Southern California Leonard Davis School of Gerontology, Los Angeles, CA, USA.
Kathleen E RodgersCenter for Innovations in Brain Science, Department of Pharmacology, University of Arizona, Tucson, AZ, USA.
David BradfordCenter for Innovations in Brain Science, Department of Pharmacology, University of Arizona, Tucson, AZ, USA.
Mara MatherUniversity of Southern California Leonard Davis School of Gerontology, Los Angeles, CA, USA.
S Duke HanUniversity of Southern California Leonard Davis School of Gerontology, Los Angeles, CA, USA.
Julian F ThayerDepartment of Psychological Science, University of California, Irvine, Irvine, CA, USA.
Daniel A NationUniversity of Southern California Leonard Davis School of Gerontology, Los Angeles, CA, USA.ORCID 0000-0002-9123-0658 University of Southern California · USUniversity of California, Irvine · USUniversity of Arizona · US
Funding
Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARTHUR W TOGA · 2016 to 2026
$28.4MLocus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive DeclineR01AG082073 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BONDI, MARK W, MATHER, MARA · 2023 to 2025
$4.9MEndothelial progenitor cells and neurovascular injury in the aging brainR01AG064228 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation · 2019 to 2026
$4.5MCerebrovascular resistance in cognitive aging and Alzheimer's disease riskR01AG060049 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NATION, DANIEL A · 2020 to 2023
$2.4MMid-Career Development and Mentoring on Financial Vulnerability and Alzheimer's DiseaseK24AG081325 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DUKE HAN · 2023 to 2026
$798kNIA NIH HHS K24 AG081325NIA NIH HHS P01 AG052350NIA NIH HHS R01 AG060049NIA NIH HHS R01 AG064228NIA NIH HHS R01 AG082073
6 · The paper itselfAbstract
Background: Increased blood pressure variability (BPV) is a risk factor for cerebral small vessel disease (CSVD) and neurodegeneration, independent of age and average blood pressure, particularly in apolipoprotein E4 ( Methods: Independently living older adults (n=70) with no history of stroke or dementia were recruited from the community and underwent 5 minutes of resting beat-to-beat blood pressure monitoring, genetic testing, and brain MRI. Resting BPV, Results: Higher BPV was associated with the presence and extent of CSVD in Conclusions: Older
Indexed as
APOE4blood pressure variabilitycentral autonomic networksmall vessel disease
Identifiers
PMID38168394
PMCPMC10760290
OpenAlexW4389719556
What OpenQuestion holds
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LicenceCC BY-NC-ND
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