Evidence map›Paper›PMID 38168388›Full record

ArticlebioRxiv : the preprint server for biology2023

Loss of Endothelial TDP-43 Leads to Blood Brain Barrier Defects in Mouse Models of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.

Ashok Cheemala, Amy L Kimble, Jordan D Tyburski, Nathan K Leclair, Aamir R Zuberi, Melissa Murphy, Evan R Jellison, Bo Reese, Xiangyou Hu, Cathleen M Lutz and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 12 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ashok CheemalaCenter for Vascular Biology, University of Connecticut Medical School, Farmington, CT.ORCID 0000-0003-2259-2839
Amy L KimbleCenter for Vascular Biology, University of Connecticut Medical School, Farmington, CT.
Jordan D TyburskiCenter for Vascular Biology, University of Connecticut Medical School, Farmington, CT.ORCID 0000-0002-2450-1649
Nathan K LeclairMD/PhD Program, University of Connecticut School of Medicine, Farmington, CT.ORCID 0000-0002-0401-2549
Aamir R ZuberiRare Disease Translational Center and Technology Evaluation and Development Laboratory, The Jackson Laboratory, Bar Harbor, ME.ORCID 0000-0003-0252-9760
Melissa MurphyCenter for Vascular Biology, University of Connecticut Medical School, Farmington, CT.
Evan R JellisonDepartment of Immunology, University of Connecticut Medical School, Farmington, CT.
Bo ReeseCenter for Genome Innovation, University of Connecticut, Storrs, CT.ORCID 0000-0001-7667-5627
Xiangyou HuDepartment of Neuroscience, University of Connecticut Medical School, Farmington, CT.ORCID 0000-0002-9083-728X
Cathleen M LutzRare Disease Translational Center and Technology Evaluation and Development Laboratory, The Jackson Laboratory, Bar Harbor, ME.ORCID 0000-0003-2502-1900
Riqiang YanDepartment of Neuroscience, University of Connecticut Medical School, Farmington, CT.ORCID 0000-0001-7195-7617
Patrick A MurphyCenter for Vascular Biology, University of Connecticut Medical School, Farmington, CT.ORCID 0000-0002-2956-1042
University of Connecticut · USJackson Laboratory · US

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Paul Robson · 1985 to 2026
$61.9M
The Jackson Laboratory Center for Precision Genetics: From New Models to Novel TherapeuticsU54OD020351 · OD · JACKSON LABORATORY · PI KORSTANJE, RONNY · 2015 to 2019
$10.2M
Contributions of Endothelial RNA-binding Protein Dysregulation to Blood Brain Barrier Defects and Neurodegenerative DiseaseRF1NS117449 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MURPHY, PATRICK ANDRIES · 2020 to 2020
$2.2M
Investigation of alternative splicing in response to low and disturbed flowR00HL125727 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MURPHY, PATRICK ANDRIES · 2016 to 2018
$746k
Investigation of alternative splicing in response to low and disturbed flowK99HL125727 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MURPHY, PATRICK ANDRIES · 2015 to 2016
$250k
NCI NIH HHS P30 CA034196NHLBI NIH HHS K99 HL125727NHLBI NIH HHS R00 HL125727NIH HHS U54 OD020351NINDS NIH HHS RF1 NS117449
6 · The paper itself

Abstract

Loss of nuclear TDP-43 occurs in a wide range of neurodegenerative diseases, and specific mutations in the

Identifiers

PMID38168388
PMCPMC10760101
OpenAlexW4389722798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.