ArticlemedRxiv : the preprint server for health sciences2023
Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles.
Gabin Drouard, Zhiyang Wang, Aino Heikkinen, Maria Foraster, Jordi Julvez, Katja M Kanninen, Irene van Kamp, Matti Pirinen, Miina Ollikainen, Jaakko Kaprio
Abstract readPreprint
In one paragraphArticle in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
10 authors.
Gabin DrouardInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-3227-8483 Zhiyang WangInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-1379-3153 Aino HeikkinenInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Maria ForasterPHAGEX Research Group, Blanquerna School of Health Science, Universitat Ramon Llull (URL), Barcelona, Spain.
Jordi JulvezClinical and epidemiological Neuroscience (NeuroÈpia), Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain.
Katja M KanninenA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Irene van KampNational Institute for Public Health and the Environment, centre for Sustainability, Environment and Health, Netherlands.
Matti PirinenInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-1664-1350 Miina OllikainenInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Jaakko KaprioInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-3716-2455 Funding
The development of alcohol misuse and related problems from adolescence to early midlifeR01AA015416 · NIAAA · WASHINGTON UNIVERSITY · PI DICK, DANIELLE M, SALVATORE, JESSICA E · 2005 to 2024
$7.6MADOLESCENT ALCOHOL ABUSE: A TWIN-STUDY PERSPECTIVER37AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2000 to 2009
$2.9MTwin, molecular, and developmental approaches to understanding alcohol misuseK02AA018755 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M · 2010 to 2019
$1.3MAdolescent Alcohol Abuse: A Twin-Study PerspectiveR01AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2013 to 2017
$1.2MUSE &ABUSE OF ALCOHOL--A BEHAVIOR-GENETICS PERSPECTIVEK05AA000145 · NIAAA · INDIANA UNIVERSITY BLOOMINGTON · PI ROSE, RICHARD JOSEPH · 1992 to 1996
–BEHAVIORAL PRECURSORS OF ALCOHOLISM--TWIN FAMILY STUDIESR01AA009203 · NIAAA · INDIANA UNIVERSITY BLOOMINGTON · PI ROSE, RICHARD JOSEPH · 1994 to 1998
–NIAAA NIH HHS K02 AA018755NIAAA NIH HHS K05 AA000145NIAAA NIH HHS R01 AA009203NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R01 AA015416NIAAA NIH HHS R37 AA012502Wellcome Trust
6 · The paper itselfAbstract
Whether differences in lifestyle between co-twins are reflected in differences in their internal or external exposome profiles remains largely underexplored. We therefore investigated whether within-pair differences in lifestyle were associated with within-pair differences in exposome profiles across four domains: the external exposome, proteome, metabolome and epigenetic age acceleration (EAA). For each domain, we assessed the similarity of co-twin profiles using Gaussian similarities in up to 257 young adult same-sex twin pairs (54% monozygotic). We additionally tested whether similarity in one domain translated into greater similarity in another. Results suggest that a lower degree of similarity in co-twins' exposome profiles was associated with greater differences in their behavior and substance use. The strongest association was identified between excessive drinking behavior and the external exposome. Overall, our study demonstrates how social behavior and especially substance use are connected to the internal and external exposomes, while controlling for familial confounders.
Indexed as
environment and geneticsEpigenetic Age AccelerationMulti-omics; ExposomeProteome; MetabolomeTwinswithin-pair proximity scores (WPPS)
Identifiers
PMID38168348
PMCPMC10760270
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