Evidence map›Paper›PMID 38168320›Full record

ArticlebioRxiv : the preprint server for biology2023

Protein phosphatases regulate the formation of Müller glia-derived progenitor cells in the chick retina.

Lisa E Kelly, Heithem M El-Hodiri, Andrew Crider, Andy J Fischer

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lisa E KellyDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH.
Heithem M El-HodiriDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH.ORCID 0000-0002-5847-4298
Andrew CriderDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH.
Andy J FischerDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH.ORCID 0000-0001-6123-7405
The Ohio State University · US

Funding

Muller glia: roles in retinal homeostasis and neuronal regenerationR01EY022030 · NEI · OHIO STATE UNIVERSITY · PI FISCHER, ANDY J · 2012 to 2021
$3.5M
Fatty acid binding-proteins and endocannabinoids in the retina; roles in glial reactivity and reprogramming of Muller glia into progenitor cellsR01EY032141 · NEI · OHIO STATE UNIVERSITY · PI FISCHER, ANDY J · 2021 to 2025
$1.9M
NEI NIH HHS R01 EY022030NEI NIH HHS R01 EY032141
6 · The paper itself

Abstract

Different kinase-dependent cell signaling pathways are known to play important roles in glia-mediated neuroprotection and reprogramming of Müller glia (MG) into Müller glia-derived progenitor cells (MGPCs) in the retina. However, very little is known about the phosphatases that regulate kinase-dependent signaling in MG. Using single-cell RNA-sequencing (scRNA-seq) databases, we investigated patterns of expression of Dual Specificity Phosphatases (DUSP1/6) and other protein phosphatases in normal and damaged chick retinas. We found that

Identifiers

PMID38168320
PMCPMC10760049
OpenAlexW4389611559

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.