Evidence map›Paper›PMID 38168289›Full record

ArticlebioRxiv : the preprint server for biology2024

ROR2 regulates cellular plasticity in pancreatic neoplasia and adenocarcinoma.

Simone Benitz, Alec Steep, Malak Nasser, Jonathan Preall, Ujjwal M Mahajan, Holly McQuithey, Ian Loveless, Erick T Davis, Hui-Ju Wen, Daniel W Long and 13 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 6 institutions in 2 countries.

Simone BenitzDepartment of Surgery, Henry Ford Health System, Detroit, Michigan, USA.
Alec SteepCenter of Translational Data Science, University of Chicago, Chicago, Illinois, USA.
Malak NasserDepartment of Surgery, Henry Ford Health System, Detroit, Michigan, USA.
Jonathan PreallCold Spring Harbor Laboratory Cancer Center, Cold Spring Harbor, New York, USA.
Ujjwal M MahajanDepartment of Medicine II, University Hospital, LMU Munich, Munich, Germany.
Holly McQuitheyDepartment of Surgery, Henry Ford Health System, Detroit, Michigan, USA.
Ian LovelessDepartment of Public Health Sciences, Henry Ford Health System, Detroit, Michigan, USA.
Erick T DavisDepartment of Surgery, Henry Ford Health System, Detroit, Michigan, USA.
Hui-Ju WenDepartment of Surgery, Henry Ford Health System, Detroit, Michigan, USA.
Daniel W LongDepartment of Surgery, Henry Ford Health System, Detroit, Michigan, USA.
Thomas MetzlerComparative Experimental Pathology (CEP), Institute of Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany.
Samuel ZwernikDepartment of Surgery, Henry Ford Health System, Detroit, Michigan, USA.
Michaela LouwDepartment of Surgery, Henry Ford Health System, Detroit, Michigan, USA.
Donald RempinskiDepartment of Surgery, Henry Ford Health System, Detroit, Michigan, USA.
Daniel Salas-EscabillasDepartment of Surgery, Henry Ford Health System, Detroit, Michigan, USA.
Sydney BrenderDepartment of Surgery, Henry Ford Health System, Detroit, Michigan, USA.
Linghao SongCenter of Translational Data Science, University of Chicago, Chicago, Illinois, USA.
Ling HuangDepartment of Surgery, Henry Ford Health System, Detroit, Michigan, USA.
Zhenyu ZhangCenter of Translational Data Science, University of Chicago, Chicago, Illinois, USA.
Nina G SteeleDepartment of Surgery, Henry Ford Health System, Detroit, Michigan, USA.
Ivonne RegelDepartment of Medicine II, University Hospital, LMU Munich, Munich, Germany.
Filip BednarDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-5193-9817
Howard C CrawfordDepartment of Surgery, Henry Ford Health System, Detroit, Michigan, USA.
Henry Ford Health System · USUniversity of Chicago · USLMU Klinikum · DECold Spring Harbor Laboratory · USTechnical University of Munich · DEUniversity of Michigan · US

Funding

Fibroblast orchestration of the immune response in pancreatic cancerU01CA274154 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Howard C. Crawford, Timothy Louis Frankel · 2022 to 2026
$4.2M
Interrupting Cellular Crosstalk in the Immunosuppressive Microenvironment of Pancreas CancerU01CA224145 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CRAWFORD, HOWARD C., PASCA DI MAGLIANO, MARINA · 2017 to 2021
$2.6M
NCI NIH HHS U01 CA224145NCI NIH HHS U01 CA274154
6 · The paper itself

Abstract

Cellular plasticity is a hallmark of pancreatic ductal adenocarcinoma (PDAC) starting from the conversion of normal cells into precancerous lesions to the progression of carcinoma subtypes associated with aggressiveness and therapeutic response. We discovered that normal acinar cell differentiation, maintained by the transcription factor Pdx1, suppresses a broad gastric cell identity that is maintained in metaplasia, neoplasia, and the classical subtype of PDAC in mouse and human. We have identified the receptor tyrosine kinase Ror2 as marker of a gastric metaplasia (SPEM)-like identity in the pancreas. Ablation of

Identifiers

PMID38168289
PMCPMC10760092
OpenAlexW4389721665

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.