Evidence map›Paper›PMID 38168273›Full record

ArticlebioRxiv : the preprint server for biology2023

PIEZO2-dependent rapid pain system in humans and mice.

Otmane Bouchatta, Marek Brodzki, Houria Manouze, Gabriela B Carballo, Emma Kindström, Felipe M de-Faria, Huasheng Yu, Anika R Kao, Oumie Thorell, Jaquette Liljencrantz and 19 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 7 institutions in 5 countries.

Otmane BouchattaCenter for Social and Affective Neuroscience, Linköping University, Linköping, Sweden.
Marek BrodzkiCenter for Social and Affective Neuroscience, Linköping University, Linköping, Sweden.
Houria ManouzeCenter for Social and Affective Neuroscience, Linköping University, Linköping, Sweden.
Gabriela B CarballoCenter for Social and Affective Neuroscience, Linköping University, Linköping, Sweden.
Emma KindströmCenter for Social and Affective Neuroscience, Linköping University, Linköping, Sweden.
Felipe M de-FariaCenter for Social and Affective Neuroscience, Linköping University, Linköping, Sweden.
Huasheng YuDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Anika R KaoSchool of Engineering and Applied Science, University of Virginia, Charlottesville, USA.
Oumie ThorellCenter for Social and Affective Neuroscience, Linköping University, Linköping, Sweden.
Jaquette LiljencrantzNational Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, USA.
Kevin K W NgCenter for Social and Affective Neuroscience, Linköping University, Linköping, Sweden.
Eleni FrangosNational Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, USA.
Bengt RagnemalmCenter for Social and Affective Neuroscience, Linköping University, Linköping, Sweden.
Dimah SaadeNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, USA.
Diana Bharucha-GoebelNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, USA.
Ilona SzczotCenter for Social and Affective Neuroscience, Linköping University, Linköping, Sweden.
Warren MooreInstitute of Life Course and Medical Sciences, University of Liverpool, UK.
Katarzyna TerejkoCenter for Social and Affective Neuroscience, Linköping University, Linköping, Sweden.
Jonathan ColeUniversity Hospitals, Dorset, and University of Bournemouth, UK.
Carsten BonnemannNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, USA.
Wenquin LuoDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
David A MahnsSchool of Medicine, Western Sydney University, Sydney, Australia.
Max LarssonCenter for Social and Affective Neuroscience, Linköping University, Linköping, Sweden.
Gregory J GerlingSchool of Engineering and Applied Science, University of Virginia, Charlottesville, USA.
Andrew G MarshallCenter for Social and Affective Neuroscience, Linköping University, Linköping, Sweden.
Alexander T CheslerNational Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, USA.
Håkan OlaussonCenter for Social and Affective Neuroscience, Linköping University, Linköping, Sweden.
Saad S NagiCenter for Social and Affective Neuroscience, Linköping University, Linköping, Sweden.ORCID 0000-0001-8773-8232
Marcin SzczotCenter for Social and Affective Neuroscience, Linköping University, Linköping, Sweden.ORCID 0000-0002-3902-059X
Linköping University · SENational Institutes of Health · USUniversity of Pennsylvania · USUniversity of Virginia · USBournemouth University · GBUniversity of Liverpool · GBWestern Sydney University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The PIEZO2 ion channel is critical for transducing light touch into neural signals but is not considered necessary for transducing acute pain in humans. Here, we discovered an exception - a form of mechanical pain evoked by hair pulling. Based on observations in a rare group of individuals with PIEZO2 deficiency syndrome, we demonstrated that hair-pull pain is dependent on PIEZO2 transduction. Studies in control participants showed that hair-pull pain triggered a distinct nocifensive response, including a nociceptive reflex. Observations in rare Aβ deafferented individuals and nerve conduction block studies in control participants revealed that hair-pull pain perception is dependent on Aβ input. Single-unit axonal recordings revealed that a class of cooling-responsive myelinated nociceptors in human skin is selectively tuned to painful hair-pull stimuli. Further, we pharmacologically mapped these nociceptors to a specific transcriptomic class. Finally, using functional imaging in mice, we demonstrated that in a homologous nociceptor, Piezo2 is necessary for high-sensitivity, robust activation by hair-pull stimuli. Together, we have demonstrated that hair-pulling evokes a distinct type of pain with conserved behavioral, neural, and molecular features across humans and mice.

Identifiers

PMID38168273
PMCPMC10760115
OpenAlexW4389271555

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.