Evidence map›Paper›PMID 38168262›Full record

ArticlebioRxiv : the preprint server for biology2023

Molecular Disambiguation of Heart Rate Control by the Nucleus Ambiguus.

Maira Jalil, Tatiana C Coverdell, Veronica A Gutierrez, Maisie E Crook, Jiachen Shi, Daniel S Stornetta, Dana C Schwalbe, Stephen B G Abbott, John N Campbell

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Maira JalilDepartment of Biology, University of Virginia, Charlottesville, VA.
Tatiana C CoverdellDepartment of Pharmacology, University of Virginia, Charlottesville, VA.
Veronica A GutierrezDepartment of Biology, University of Virginia, Charlottesville, VA.
Maisie E CrookDepartment of Biology, University of Virginia, Charlottesville, VA.
Jiachen ShiDepartment of Biology, University of Virginia, Charlottesville, VA.
Daniel S StornettaDepartment of Pharmacology, University of Virginia, Charlottesville, VA.
Dana C SchwalbeDepartment of Biology, University of Virginia, Charlottesville, VA.
Stephen B G AbbottDepartment of Pharmacology, University of Virginia, Charlottesville, VA.
John N CampbellDepartment of Biology, University of Virginia, Charlottesville, VA.ORCID 0000-0002-3943-8312
University of Virginia · USUniversity of Missouri · US

Funding

TRAINING IN THE PHARMACOLOGICAL SCIENCEST32GM007055 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LYNCH, KEVIN R. · 1985 to 2022
$7.2M
Molecular and Functional Taxonomy of Cardiovagal NeuronsR01HL153916 · NHLBI · UNIVERSITY OF VIRGINIA · PI CAMPBELL, JOHN NELSON · 2021 to 2025
$3.1M
Role of presympathetic neurons of the hindbrain in cardiovascular controlR01HL148004 · NHLBI · UNIVERSITY OF VIRGINIA · PI ABBOTT, STEPHEN · 2019 to 2023
$2.6M
Identification of cell-type specific visual circuits in the ventral lateral geniculate nucleusR21EY033528 · NEI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI CAMPBELL, JOHN N, FOX, MICHAEL A · 2022 to 2023
$441k
Genetic Dissection of Nucleus Ambiguus Neurons Controlling Cardiorespiratory FunctionsF31HL158187 · NHLBI · UNIVERSITY OF VIRGINIA · PI COVERDELL, TATIANA CLARISSA · 2021 to 2022
$46k
NEI NIH HHS R21 EY033528NHLBI NIH HHS F31 HL158187NHLBI NIH HHS R01 HL148004NHLBI NIH HHS R01 HL153916NIGMS NIH HHS T32 GM007055
6 · The paper itself

Abstract

The nucleus ambiguus (nAmb) provides parasympathetic control of cardiorespiratory functions as well as motor control of the upper airways and striated esophagus. A subset of nAmb neurons innervates the heart through the vagus nerve to control cardiac function at rest and during key autonomic reflexes such as the mammalian diving reflex. These cardiovagal nAmb neurons may be molecularly and anatomically distinct, but how they differ from other nAmb neurons in the adult brain remains unclear. We therefore classified adult mouse nAmb neurons based on their genome-wide expression profiles, innervation of cardiac ganglia, and ability to control HR. Our integrated analysis of single-nucleus RNA-sequencing data predicted multiple molecular subtypes of nAmb neurons. Mapping the axon projections of one nAmb neuron subtype, Npy2r-expressing nAmb neurons, showed that they innervate cardiac ganglia. Optogenetically stimulating all nAmb vagal efferent neurons dramatically slowed HR to a similar extent as selectively stimulating

Identifiers

PMID38168262
PMCPMC10760142
OpenAlexW4389856279

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.