ArticlebioRxiv : the preprint server for biology2024
The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during aging.
Liam C Hunt, Kudzai Nyamkondiwa, Anna Stephan, Jianqin Jiao, Kanisha Kavdia, Vishwajeeth Pagala, Junmin Peng, Fabio Demontis
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 3 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors at 1 institution in 1 country.
Liam C HuntDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Kudzai NyamkondiwaDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Anna StephanDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jianqin JiaoDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Kanisha KavdiaCenter for Proteomics and Metabolomics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Vishwajeeth PagalaCenter for Proteomics and Metabolomics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Junmin PengDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Fabio DemontisDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-8698-9555 St. Jude Children's Research Hospital · US
Funding
Dissecting neuron-microglia-astrocyte interaction in AD pathogenesisRF1AG068581 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PENG, JUNMIN, ROSSOLL, WILFRIED · 2020 to 2023
$5.4MRegulation of Mitochondrial Gene Expression and Function by GDF11 SignalingR01AG055532 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI DEMONTIS, FABIO · 2017 to 2021
$2.3MMapping tauopathy-induced changes in subcellular proteostasis with compartment-targeted sensorsR21AG079267 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI DEMONTIS, FABIO · 2022 to 2022
$501kNIA NIH HHS R01 AG055532NIA NIH HHS R21 AG079267NIA NIH HHS RF1 AG068581
6 · The paper itselfAbstract
Ubiquitin-conjugating enzymes (E2s) are key for regulating protein function and turnover via ubiquitination but it remains undetermined which E2s maintain proteostasis during aging. Here, we find that E2s have diverse roles in handling a model aggregation-prone protein (huntingtin-polyQ) in the
Indexed as
agingE2 ubiquitin-conjugating enzymeshuntingtininsoluble poly-ubiquitinated proteinsprotein quality controlproteostasisskeletal muscleUBE2Dubiquitination
Identifiers
PMID38168249
PMCPMC10759998
OpenAlexW4389687163
What OpenQuestion holds
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LicenceCC BY
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