Evidence map›Paper›PMID 38168227›Full record

ArticleResearch square2023

Transgelin 2 guards T cell lipid metabolic programming and anti-tumor function.

Sung-Min Hwang, Deepika Awasthi, Jieun Jeong, Tito A Sandoval, Chang-Suk Chae, Yusibeska Ramos, Chen Tan, Matías Marin Falco, Ian T McBain, Bikash Mishra and 12 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 8 institutions in 3 countries.

Sung-Min HwangDepartment of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.ORCID 0000-0002-4868-147X
Deepika AwasthiDepartment of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.
Jieun JeongCancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Tito A SandovalDepartment of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.ORCID 0000-0003-2705-5282
Chang-Suk ChaeDepartment of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.
Yusibeska RamosDepartment of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.
Chen TanDepartment of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.
Matías Marin FalcoResearch Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Ian T McBainWeill Cornell Graduate School of Medical Sciences. New York, NY 10065. USA.
Bikash MishraWeill Cornell Graduate School of Medical Sciences. New York, NY 10065. USA.
Lionel B IvashkivWeill Cornell Graduate School of Medical Sciences. New York, NY 10065. USA.ORCID 0000-0002-9951-0646
Dmitriy ZamarinTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Evelyn CantilloDepartment of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.
Eloise Chapman-DavisDepartment of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.
Kevin HolcombDepartment of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.
Diana K MoralesDepartment of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.
Paulo C RodriguezDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute. Tampa, FL, USA.
Jose R Conejo-GarciaDepartment of Integrated Immunobiology, Duke School of Medicine, Durham, NC 27710, USA.ORCID 0000-0001-6431-4074
Martin KaczochaDepartment of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.
Anna VähärautioResearch Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-4721-3954
Minkyung SongDepartment of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.ORCID 0000-0003-2668-7528
Juan R Cubillos-RuizDepartment of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.ORCID 0000-0002-4267-4893
Cornell University · USHospital for Special Surgery · USUniversity of Helsinki · FIDuke University · USIcahn School of Medicine at Mount Sinai · USMemorial Sloan Kettering Cancer Center · USMoffitt Cancer Center · USStony Brook School · US

Funding

Project 4P01CA250984 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RODRIGUEZ, PAULO CESAR · 2021 to 2025
$10.1M
Development of the Next Generation of FABP5 Inhibitors to Treat Prostate CancerR01CA237154 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI KACZOCHA, MARTIN, OJIMA, IWAO · 2020 to 2024
$3.3M
ER stress-driven IRE1a-XBP1 signaling in lung cancerR01CA271619 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Juan R Cubillos-Ruiz, Vivek Mittal · 2023 to 2026
$2.6M
POTENTIATION OF ANTI-TUMOR IMMUNITY BY ONCOLYTIC VIRUS IN SITU VACCINATIONR01CA269382 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Dmitriy Zamarin · 2023 to 2026
$2.5M
Immunometabolic Programs Controlled by ER Stress in CancerR01CA282072 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Juan R Cubillos-Ruiz · 2023 to 2026
$2.3M
Plant-derived extracts regulate immunosuppressive myelopoiesis in Breast cancer patientsR01CA262121 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RODRIGUEZ, PAULO CESAR · 2021 to 2025
$2.1M
Endoplasmic Reticulum Stress Responses in PainR01NS114653 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BOADA, MARIO DANILO, ROMERO-SANDOVAL, E. ALFONSO · 2020 to 2024
$2.0M
Functional reprogramming of tumor-MDSC through antibody-based therapies targeting Notch ligandsR01CA233512 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RODRIGUEZ, PAULO CESAR · 2019 to 2023
$2.0M
Mitochondrial stress promotes immunosuppressive potential of myeloid subsets in tumorsR01CA273034 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RODRIGUEZ, PAULO CESAR · 2022 to 2025
$1.9M
NCI NIH HHS P01 CA250984NCI NIH HHS R01 CA233512NCI NIH HHS R01 CA237154NCI NIH HHS R01 CA262121NCI NIH HHS R01 CA269382NCI NIH HHS R01 CA271619NCI NIH HHS R01 CA273034NCI NIH HHS R01 CA282072NINDS NIH HHS R01 NS114653
6 · The paper itself

Abstract

Mounting effective immunity against pathogens and tumors relies on the successful metabolic programming of T cells by extracellular fatty acids

Identifiers

PMID38168227
PMCPMC10760247
OpenAlexW4389703165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.