Evidence map›Paper›PMID 38168223›Full record

ArticlebioRxiv : the preprint server for biology2023

Glucocerebrosidase deficiency leads to neuropathology via cellular immune activation.

Evelyn S Vincow, Ruth E Thomas, Gillian Milstein, Gautam Pareek, Theo Bammler, James MacDonald, Leo Pallanck

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Evelyn S VincowDepartment of Genome Sciences, University of Washington, Seattle, Washington, United States of America.ORCID 0000-0002-7449-3173
Ruth E ThomasDepartment of Genome Sciences, University of Washington, Seattle, Washington, United States of America.ORCID 0000-0001-9648-2339
Gillian MilsteinDepartment of Genome Sciences, University of Washington, Seattle, Washington, United States of America.
Gautam PareekDepartment of Genome Sciences, University of Washington, Seattle, Washington, United States of America.
Theo BammlerDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, United States of America.
James MacDonaldDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, United States of America.
Leo PallanckDepartment of Genome Sciences, University of Washington, Seattle, Washington, United States of America.ORCID 0000-0002-5943-9339
University of Washington · US

Funding

Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI Sandra E Juul · 2020 to 2026
$9.9M
Mechanism of innate immune activation in a Drosophila model of Alzheimer's disease related dementiaR01AG075100 · NIA · UNIVERSITY OF WASHINGTON · PI Leo J Pallanck · 2022 to 2026
$1.9M
Mechanism and importance of innate immune activation in a Drosophila GBA mutant model of Parkinson's diseaseR21AG068356 · NIA · UNIVERSITY OF WASHINGTON · PI PALLANCK, LEO J · 2020 to 2021
$428k
NIA NIH HHS R01 AG075100NIA NIH HHS R21 AG068356NICHD NIH HHS P50 HD103524
6 · The paper itself

Abstract

Mutations in

Identifiers

PMID38168223
PMCPMC10760128
OpenAlexW4389702569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.