Evidence map›Paper›PMID 38168212›Full record

ArticlebioRxiv : the preprint server for biology2023

Biosynthesis of Strained Amino Acids Through a PLP-Dependent Enzyme via Cryptic Halogenation.

Max B Sosa, Jacob T Leeman, Lorenzo J Washington, Henrik V Scheller, Michelle C Y Chang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Max B SosaDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720 USA.ORCID 0009-0008-8230-6535
Jacob T LeemanDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720 USA.
Lorenzo J WashingtonDepartment of Plant & Microbial Biology, University of California, Berkeley, Berkeley, CA 94720 and Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.ORCID 0000-0002-0624-4693
Henrik V SchellerDepartment of Plant & Microbial Biology, University of California, Berkeley, Berkeley, CA 94720 and Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.ORCID 0000-0002-6702-3560
Michelle C Y ChangDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720 USA and Department of Chemical & Biomolecular Engineering, University of California, Berkeley, Berkeley, CA 94720 USA and Department of Molecular & Cell Biology, University of California, Berkeley, Berkeley, CA 94720 USA.

Funding

Univ of Calif Berkeley Chemistry-Biology Interface ProgramT32GM066698 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, CHRISTOPHER J., FRANCIS, MATTHEW B · 2004 to 2023
$7.5M
Proposal for Central California 900 MHZ NMR SpectrometerP41GM068933 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI WEMMER, DAVID E · 2003 to 2007
$5.9M
Discovery and Application of New HalogenasesR01GM134271 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, MICHELLE C · 2020 to 2023
$1.5M
Acquisition of a Cryoprobe and Related Accessories for a 600 MHz NMR Spectrometer to Support Health Research Activities at the University of California, BerkeleyS10OD024998 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARTWIG, JOHN F · 2018 to 2018
$265k
NIGMS NIH HHS P41 GM068933NIGMS NIH HHS R01 GM134271NIGMS NIH HHS T32 GM066698NIH HHS S10 OD024998
6 · The paper itself

Abstract

Amino acids (AAs) are modular and modifiable building blocks which nature uses to synthesize both macromolecules, such as proteins, and small molecule natural products, such as alkaloids and non-ribosomal peptides (NRPs). While the 20 main proteinogenic AAs display relatively limited side-chain diversity, a wide range of non-canonical amino acids (ncAAs) exist that are not used by the ribosome for protein synthesis but contain a broad array of structural features and functional groups not found in proteinogenic AAs. In this communication, we report the discovery of the biosynthetic pathway for a new ncAA, pazamine, which contains a cyclopropane ring formed in two steps. In the first step, a chlorine is added onto the C

Indexed as

biosynthesiscyclobutanecyclopropanehalogenasenon-canonical amino acidspyridoxal phosphate (PLP)

Identifiers

PMID38168212
PMCPMC10760155

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.